Zachary Burke, MD
Associate Staff
Location: Cleveland Clinic Main Campus
Research
The Zachary Burke lab studies novel treatments for prosthetic joint infection, sarcoma therapies and clinical outcomes in orthopaedic sarcoma surgery.
Biography
Zachary Burke, MD is an orthopaedic oncologist in the Sarcoma Program of the Department of Orthopedic Surgery at Cleveland Clinic. He completed his medical and orthopaedic training at UCLA where he was inducted into the Alpha Omega Alpha (AOA) honor society. He continued his training with a fellowship in orthopaedic oncology at Mount Sinai Hospital, Princess Margaret Cancer Center, and the Hospital for Sick Children at the University of Toronto. He specializes in pediatric and adult bone sarcoma, limb sparing surgical techniques, soft tissue sarcoma, benign tumors, and metastatic bone disease. Patient-centered care is his passion.
As a surgeon-scientist, Dr. Burke is very active in research in Cleveland Clinic's Lerner Research Institute (LRI) as a translational scientist. His research interests include novel treatments for prosthetic joint infection, sarcoma therapies, and clinical outcomes in orthopaedic sarcoma surgery. He completed a research fellowship at the Orthopaedic Hospital Research Center at UCLA and was awarded a Ruth L. Kirschstein National Research Service Award (T32) from the National Institutes of Health (NIH) in support of his work. He has numerous publications in both translational science and clinical research, has authored several book chapters, and has presented widely at national and international meetings. He is a member of the American Academy of Orthopaedic Surgeons (AAOS), Musculoskeletal Tumor Society (MSTS), and Connective Tissue Oncology Society (CTOS).
Dr. Burke lives in Cleveland and devotes his time outside of the Clinic to his wife, three children, and dog.
Education & Professional Highlights
Education & FellowshipsFellowship - University of Toronto/Princess Margaret Cancer Center
Musculoskeletal Oncology
Toronto, ON Canada
2022
Residency - UCLA Medical Center, Department of Orthopedic Surgery
Orthopedic Surgery
Los Angeles, CA USA
2021
Fellowship - Orthopedic Hospital Research Center, University of California, Los Angeles (UCLA
Postdoctoral research fellow
Los Angeles, CA USA
2018
Internship - University of California Los Angeles Medical Center (UCLA)
General Surgery
Los Angeles, CA USA
2016
Medical Education - University of California, Los Angeles (UCLA)
Los Angeles, CA USA
2015
Undergraduate - Pomona College
Neuroscience
Claremont, CA USA
2010
Research
Our Team
Selected Publications
Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model. Antibiotics (Basel). 2023. 37887191.
Oyem Precious C, Burke Zachary D, Mesko Nathan W, Nystrom Lukas M. Custom three-dimensional printed implants for reconstruction of oncologic pelvic defects. J Surg Oncol. 2023. 37754672.
Open Versus Core Needle Biopsy in Lower-Extremity Sarcoma: Current Practice Patterns and Patient Outcomes. J Bone Joint Surg Am. 2023. 37466581.
Is a radiological score able to predict resection-grade chondrosarcoma in primary intraosseous lesions of the long bones? Bone Joint J. 2023. 37391201.