Larisa Tereshchenko Research Program

Research

Overview

Dr. Tereshchenko's research interest lies in studying the mechanisms of cardiac arrhythmias and the causal effects of cardiac arrhythmias within the cardiovascular disease continuum and developing cutting-edge tools to advance the prediction, prevention, and treatment of cardiac arrhythmias. 

As a clinical investigator, epidemiologist, biostatistician, and data scientist, Dr. Tereshchenko is interested in the methodology of clinical investigation, novel designs of randomized controlled trials and observational studies, and novel analytical approaches, focusing on causal inference. 

Current Research Projects

American Heart Association Innovative Project Award "Electrical dyssynchrony and heart failure"

Lay Summary: The heart is an electromechanical pump. A healthy heart pump works in synchrony. The synchrony of the heart pumping is provided by electricity. Lost synchrony is one of heart failure causes. We learned that we could restore synchrony with a treatment. What we still don't know well is how to detect the loss of synchrony early. This proposed study will develop an inexpensive and effective way to detect lost synchrony in the heart. Early treatment of patients with lost synchrony will prevent heart failure. "An ounce of prevention is worth a pound of cure" (Benjamin Franklin).

American Heart Association Innovative Project Award "Atrial Fibrillation Mapping Using Phase-Aligned Spectral Filtering for Decomposing Spatiotemporal Dynamics"

Lay summary: Cardiac arrhythmia in the upper chamber of the heart (atrial fibrillation) can be cured by burning. Physicians burn very small pieces of abnormal tissue. It is important to know where to burn. We propose a new way to find out where to burn. We will use a new way to analyze electrical signals inside the heart and build a new electric map. Our study will lead to new technology development. In the future, our technology will increase the success rate and the number of cured atrial fibrillation patients.

 The Caregiver  Catalyst  Grant “Natural Language Processing for adjudication of clinical outcomes in the electronic health record.” 

The study aims to develop and validate NLP models for accurate and reproducible identification/classification of prespecified clinical outcomes in electronic health records.

 The CTSC grant  “Primary prevention of sudden cardiac death.” 

The goal of the study is to validate the Global Electrical Heterogeneity risk score in two patient populations: (1) patients with ICD/CRT-D devices implanted for primary prevention of sudden cardiac death and (2) a cohort of primary care patients. 

Completed Research Projects

This ancillary ARIC and CHS study had 3 goals: (1) the discovery of novel SCD mechanisms in the general population and the development of novel mechanistic ECG risk markers of SCD; (2) the development and validation of the novel resting 12-lead ECG risk score of SCD risk in the analysis of community-dwelling cohorts of adults, and (3) discovery of genetic loci associated with the novel mechanistic ECG phenotypes.

This retrospective multicenter cohort validated an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, validated and re-calibrated GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.

This retrospective study developed the concept of electrocardiographic (ECG) global electrical heterogeneity (GEH). The study conducted analyses of two retrospective cohorts: ICD-EGMs and PROSE-ICD study ( PRospective Observational Study of the ICD in Sudden Cardiac Death).

Selected Publications

View publications for Larisa Tereshchenko, MD, PhD
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