Brittany Lapin Research Program

Research

My general research interest lies in optimizing the clinical utility of patient-reported outcome measurements (PROMs). Cleveland Clinic collects over 100,000 PROMs per month, which our team analyzes to track conditions over time, evaluate effectiveness of interventions, and determine the value of care. More specifically, my research is focused on developing and optimizing methodology to improve the utilization and interpretation of PROMs for both patient-centered care and for clinical research. 

Selected Publications

View publications for Brittany Lapin, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Aboseif Albert, Li Yadi, Amin Moein, Lapin Brittany, Milinovich Alex, Abbatemarco Justin R, Cohen Jeffrey A, Punia Vineet, Rae-Grant Alex D, Galioto Rachel, Kunchok Amy. Clinical Determinants of Longitudinal Disability in LGI-1-IgG Autoimmune Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2024. 37949667.

Simmons Sarah B, Harris Donayja, Skolaris Alexis, Fricker Tori, Li Yadi, Lapin Brittany, Galioto Rachel, Bethoux Francois, Linder Susan M. Aerobic cycling reduces fatigue and improves pain in persons with multiple sclerosis: A preliminary study. Mult Scler Relat Disord. 2023. 37925962.

Lapin Brittany, Wyllie Robert R. Addition of community paramedics to a physician home-visit program: A prospective cohort study. J Am Geriatr Soc. 2023. 37800363.

Sudarshan Monisha, Tasnim Sadia, Ramji Sadhvika, Rappaport Jesse, Barron John O, Bribriesco Alejandro C, Schraufnagel Dean P, Lapin Brittany, Li Yadi, Raymond Daniel P, Blackstone Eugene H, Murthy Sudish C, Raja Siva. Development and validation of a universal esophageal patient-reported outcome measure: The Cleveland Clinic Esophageal Questionnaire (CEQ). J Thorac Cardiovasc Surg. 2023. 37625617.

Thompson Nicolas R, Lapin Brittany R, Katzan Irene L. Utilities Estimated from PROMIS Scales for Cost-Effectiveness Analyses in Stroke. Med Decis Making. 2023. 37401739.

Ahmed Zubair, Honomichl Ryan, Schuster Andrew, Thompson Nicolas R, Lapin Brittany, Udeh Belinda L, Katzan Irene L. Clinical characteristics and patient-reported outcomes of chronic and episodic migraine patients at a US tertiary headache center: A retrospective observational study. Headache. 2023. 37314065.

Rao Shilpa C, Li Yadi, Lapin Brittany, Pattipati Sreya, Gutierrez Nicolas, Leal Thiago Peixoto, Salim Amira, Mata Ignacio F. Association of women-specific health factors in the severity of Parkinson's disease. NPJ Parkinsons Dis. 2023. 37277346.

Lapin Brittany. Development of consensus-based considerations for use of adult proxy reporting: an ISOQOL task force initiative. J Patient Rep Outcomes. 2023. 37266745.

Lapin Brittany, Li Yadi, Davin Sara, Stilphen Mary, Johnson Joshua K, Benzel Edward, Habboub Ghaith, Katzan Irene L. Comparison of stratification techniques for optimal management of patients with chronic low back pain in spine clinics. Spine J. 2023. 37149152.

Pena-Orbea Cinthya, Lapin Brittany, Li Yadi, Englund Kristin, Heinzinger Catherine, Foldvary-Schaefer Nancy, Mehra Reena. Sleep Disturbance Severity and Correlates in Post-acute Sequelae of COVID-19 (PASC). J Gen Intern Med. 2023. 37014604.

Lapin Brittany, Davin Sara, Stilphen Mary, Johnson Joshua K, Benzel Edward, Habboub Ghaith, Katzan Irene L. Stratification of spine patients based on self-reported clinical symptom classes: Evaluation of long-term outcomes and subsequent interventions. N Am Spine Soc J. 2023. 36970061.

Phelan Michael P, Thompson Nicolas R, Ahmed Zubair, Lapin Brittany, Udeh Belinda, Anderson Eric, Katzan Irene. Emergency department utilization among patients who receive outpatient specialty care for headache: A retrospective cohort study analysis. Headache. 2023. 36861814.

Leung Jason, Ghosn Samer, Lapin Brittany, Punia Vineet, Nair Dileep, Kaniecki Ann Marie, Edhi Muhammad, Saab Carl Y. SARS-CoV-2 alters neural synchronies in the brain with more severe effects in younger individuals. Sci Rep. 2023. 36807586.

Punia Vineet, Li Yadi, Lapin Brittany, Chandan Pradeep, Newey Christopher, Hantus Stephen, Katzan Irene L. Impact of acute symptomatic seizures and their management on patient-reported outcomes after stroke. Epilepsy Behav. 2023. 36804847.

Lapin Brittany, Deshpande Abhishek. Assessment of Quality of Life Among Patients With Recurrent Clostridioides difficile Infection Treated with Investigational Oral Microbiome Therapeutic SER-109: Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2023. 36716031.

Lapin Brittany, Mate Kedar, Li Yadi, Thakore Nimish. Subjective health perception prioritizes psychological well-being over physical function in advanced ALS: A multigroup structural equation modeling analysis. J Neurol Sci. 2022. 36201964.

Thakore Nimish J, Lapin Brittany R. Early initiation of riluzole may improve absolute survival in amyotrophic lateral sclerosis. Muscle Nerve. 2022. 36117390.

Lapin Brittany, Katzan Irene L. PROMIS global health: potential utility as a screener to trigger construct-specific patient-reported outcome measures in clinical care. Qual Life Res. 2023. 35947238.

McGinley Marisa P, Lapin Brittany. The value of patient-reported outcome measures for multiple sclerosis. Mult Scler. 2022. 35876470.

Thompson Nicolas R, Lapin Brittany R, Steinmetz Michael P, Benzel Edward C, Katzan Irene L. Mapping PROMIS physical function and pain interference to the modified low back pain disability questionnaire. Qual Life Res. 2022. 35794422.

Lapin Brittany, Deshpande Abhishek. Validation of a Health-Related Quality of Life Questionnaire in Patients With Recurrent Clostridioides difficile Infection in ECOSPOR III, a Phase 3 Randomized Trial. Clin Infect Dis. 2023. 35789381.

Chang Olivia H, Walters Mark D, Yao Meng, Lapin Brittany. Development and validation of the Value of Uterus instrument and visual analog scale to measure patients' valuation of their uterus. Am J Obstet Gynecol. 2022. 35764134.

Park Deborah Y, Chen Yanwen, Tewari Surabhi, Yu Jennifer S, Chao Samuel T, Suh John H, Peereboom David M, Stevens Glen H J, Barnett Gene H, Angelov Lilyana, Mohammadi Alireza, Hogan Thomas, Kissel Courtney, Lapin Brittany, Schuermeyer Isabel, Naugle Richard, Murphy Erin S. Cognitive function after concurrent temozolomide-based chemoradiation therapy in low-grade gliomas. J Neurooncol. 2022. 35486307.

. TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease. Nat Commun. 2022. 35440548.

Johnson Joshua K, Lapin Brittany, Bethoux Francois, Skolaris Alexis, Katzan Irene, Stilphen Mary. Patient Versus Clinician Proxy Reliability of the AM-PAC "6-Clicks" Basic Mobility and Daily Activity Short Forms. Phys Ther. 2022. 35385119.

Rothberg Michael B, Adams Kellie, Lapin Brittany, Stilphen Mary. Association of Physical Therapy Treatment Frequency in the Acute Care Hospital With Improving Functional Status and Discharging Home. Med Care. 2022. 35293885.

Lapin Brittany, Davin Sara, Stilphen Mary, Johnson Joshua K, Benzel Edward, Habboub Ghaith, Katzan Irene L. Stratification of spine patients based on self-reported clinical symptom classes. Spine J. 2022. 35189348.

Park Deborah Y, Wei Wei, Tewari Surabhi, Yu Jennifer S, Chao Samuel T, Suh John H, Peereboom David, Stevens Glen H J, Barnett Gene H, Angelov Lilyana, Mohammadi Alireza M, Hogan Thomas, Kissel Courtney, Lapin Brittany, Schuermeyer Isabel, Naugle Richard, Murphy Erin S. Quality of life following concurrent temozolomide-based chemoradiation therapy or observation in low-grade glioma. J Neurooncol. 2022. 35064450.

Lapin Brittany, Katzan Irene L. Health-Related Quality of Life Mildly Affected Following COVID-19: a Retrospective Pre-post Cohort Study with a Propensity Score-Matched Control Group. J Gen Intern Med. 2022. 35025068.

Lapin Brittany, Thompson Nicolas, Schuster Andrew, Katzan Irene L. Optimal Methods for Reducing Proxy-Introduced Bias on Patient-Reported Outcome Measurements for Group-Level Analyses. Circ Cardiovasc Qual Outcomes. 2021. 34724804.

Lapin Brittany R, Tang Wai Hong Wilson, Honomichl Ryan, Hogue Olivia, Katzan Irene L. Evidence of Stability in Patient-Reported Global Health During the COVID-19 Pandemic. Value Health. 2021. 34711357.

Han Zheyi, Lapin Brittany, Donskey Curtis J, Deshpande Abhishek. Impact of infection on patient-reported quality of life. Infect Control Hosp Epidemiol. 2022. 34615561.

Katzan Irene L, Schuster Andrew, Daboul Lynn, Doherty Christine, Speaker Sidra, Uchino Ken, Lapin Brittany. Changes in Health-Related Quality of Life After Transient Ischemic Attack. JAMA Netw Open. 2021. 34283228.

Lapin Brittany R, Thompson Nicolas R, Schuster Andrew, Katzan Irene L. Patient-proxy agreement on change in acute stroke patient-reported outcome measures: a prospective study. J Patient Rep Outcomes. 2021. 34228242.

Merner Amanda R, Ford Paul J, Machado Andre, Lapin Brittany, Kubu Cynthia S. Changes in Patients' Desired Control of Their Deep Brain Stimulation and Subjective Global Control Over the Course of Deep Brain Stimulation. Front Hum Neurosci. 2021. 33732125.

Katzan Irene L, Lapin Brittany, Griffith Sandra, Jehi Lara, Fernandez Hubert, Pioro Erik, Tepper Stewart. Somatic symptoms have negligible impact on Patient Health Questionnaire-9 depression scale scores in neurological patients. Eur J Neurol. 2021. 33715277.

Katzan Irene L, Thompson Nicolas, Schuster Andrew, Wisco Dolora, Lapin Brittany. Patient-Reported Outcomes Predict Future Emergency Department Visits and Hospital Admissions in Patients With Stroke. J Am Heart Assoc. 2021. 33666094.

Thakore Nimish J, Lapin Brittany R, Pioro Erik P. Progressive arm muscle weakness in ALS follows the same sequence regardless of onset site: use of TOMS, a novel analytic method to track limb strength. Amyotroph Lateral Scler Frontotemporal Degener. 2021. 33620270.

Lapin Brittany R, Thompson Nicolas R, Schuster Andrew, Honomichl Ryan, Katzan Irene L. The validity of proxy responses on patient-reported outcome measures: Are proxies a reliable alternative to stroke patients' self-report? Qual Life Res. 2021. 33511498.

Thakore Nimish J, Pioro Erik P, Udeh Belinda L, Lapin Brittany R, Katzan Irene L. A Cost-Effectiveness Framework for Amyotrophic Lateral Sclerosis, Applied to Riluzole. Value Health. 2020. 33248509.

Rose Susannah. The influence of collecting patient-reported outcome measures on visit satisfaction in rheumatology clinics. Rheumatol Adv Pract. 2020. 33173849.

Lapin Brittany R, Honomichl Ryan, Thompson Nicolas, Rose Susannah, Abelson Abby, Deal Chad, Katzan Irene L. Patient-reported experience with patient-reported outcome measures in adult patients seen in rheumatology clinics. Qual Life Res. 2021. 33170400.

Miller Margaret, Honomichl Ryan, Lapin Brittany, Hogan Thomas, Thompson Nicholas, Jehi Lara, Busch Robyn M. The memory assessment clinics scale for epilepsy (MAC-E): A brief measure of subjective cognitive complaints in epilepsy. Clin Neuropsychol. 2022. 33106081.

Lapin Brittany R, Thompson Nicolas R, Schuster Andrew, Katzan Irene L. Magnitude and Variability of Stroke Patient-Proxy Disagreement Across Multiple Health Domains. Arch Phys Med Rehabil. 2021. 33035512.

Johnson Joshua K, Lapin Brittany, Green Karen, Stilphen Mary. Frequency of Physical Therapist Intervention Is Associated With Mobility Status and Disposition at Hospital Discharge for Patients With COVID-19. Phys Ther. 2021. 32986836.

Lapin Brittany R. Considerations for Reporting and Reviewing Studies Including Health-Related Quality of Life. Chest. 2020. 32658652.

Lapin Brittany R, Pantalone Kevin M, Milinovich Alex, Morrison Shannon, Schuster Andrew, Thakore Nimish J. Pain in Patients With Type 2 Diabetes-Related Polyneuropathy Is Associated With Vascular Events and Mortality. J Clin Endocrinol Metab. 2020. 32575118.

Newey Christopher R, Thompson Nicolas R, George Pravin, Punia Vineet, Hantus Stephen, Lapin Brittany, Gomes Joao, Katzan Irene. Patient-Reported Outcomes (PROs) in Acute Symptomatic Seizure (ASyS) Versus Patients With Established Epilepsy. Neurohospitalist. 2020. 32549943.

Lapin Brittany, Majhail Navneet S, Hamilton Betty K. Patient-reported outcomes in acute graft-versus-host disease: optimizing patient care and clinical trial endpoints. Bone Marrow Transplant. 2020. 32157245.

Davin Sara. Comparative Effectiveness of an Interdisciplinary Pain Program for Chronic Low Back Pain, Compared to Physical Therapy Alone. Spine (Phila Pa 1976). 2019. 31794508.

A. Determination of the value of patient-reported outcomes measurements (PROMs)

The added value of PROMs to clinical-reported measures: 

• Katzan L, Thompson NR, Lapin B, Uchino K. Added Value of Patient-Reported Outcome Measures in Stroke Clinical Practice Journal of the American Heart Association vol. 6,7 e005356. 21 Jul. 2017, doi:10.1161/JAHA.116.005356
  
  

B. Optimization of the clinical utility of PROMs

Linking two common PROMs in clinical practice to assess global health in patients with spine disorder

• Lapin BR, Kinzy TG, Thompson NR, Krishnaney A, Katzan IL. Accuracy of Linking VR-12 and PROMIS Global Health Scores in Clinical Practice. Value Health. 2018 Oct;21(10):1226-1233. doi: 10.1016/j.jval.2018.03.011. Epub 2018 Apr 26= 

Validating the PROMIS Global Health in stroke patients:

• Katzan IL, Lapin B. PROMIS GH (Patient-Reported Outcomes Measurement Information System Global Health) Scale in Stroke: A Validation Study. Stroke. 2018 Jan;49(1):147-154

Accurate methodology for linking two common PROMs to assess global health:

• Thompson NR, Lapin BR, Katzan IL. Mapping PROMIS Global Health Items to EuroQol (EQ-5D) Utility Scores Using Linear and Equipercentile Equating. Pharmacoeconomics. 2017 Nov;35(11):1167-1176.

C. Application of item response theory models to improve PROMs

Demonstrating the unidimensionality of the Epworth Sleepiness Scale:

• Lapin BR, Bena JF, Walia HK, Moul DE. The Epworth Sleepiness Scale: Validation of One-Dimensional Factor Structure in a Large Clinical Sample. J Clin Sleep Med. 2018 Aug 15;14(8):1293-1301

D. Evaluation of patient conditions and interventions through PROMs

PROMs across stroke type:

• Katzan IL, Schuster A, Newey C, Uchino K, Lapin BR. Patient-reported outcomes across cerebrovascular event types: More similar than different. Neurology. 2018 Dec 4;91(23):e2182-e2191

Affected health domains after ischemic stroke:

• Katzan IL, Thompson NR, Uchino K, Lapin BR. The most affected health domains after ischemic stroke. Neurology. 2018 Apr 17;90(16):e1364-e1371

A Markov modeling approach to assessing ALS progression:

• Thakore NJ, Lapin BR, Kinzy TG, Pioro EP. Deconstructing progression of amyotrophic lateral sclerosis in stages: a Markov modeling approach. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):483-494

Trajectories of impairments in ALS:

• Thakore NJ, Lapin BR, Pioro EP. Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open-Access ALS Clinical Trials cohort. Muscle Nerve. 2018 Jun;57(6):937-945 

Cognitive impairments in adult patients with epilepsy:

• Feldman L, Lapin BR, Busch RM, Bautista JF. Evaluating subjective cognitive impairment in the adult epilepsy clinic: Effects of depression, number of antiepileptic medications, and seizure frequency. Epilepsy Behav. 2018 Apr;81:18-24.

E. Assessment of patient-reported depression across conditions

Depression across neurological conditions:

• Viguera AC, Fan Y, Thompson NR, Lapin BR, Chaitoff A, Griffith SD, Miller DM, Jehi L, Katzan IL. Prevalence and Predictors of Depression Among Patients With Epilepsy, Stroke, and Multiple Sclerosis Using the Cleveland Clinic Knowledge Program Within the Neurological Institute. Psychosomatics. 2018 Jul - Aug;59(4):369-378. 

Depression in bariatric surgery patients with multiple sclerosis:

• Fisher CJ, Heinberg LJ, Lapin BR, Aminian A, Sullivan AB. Depressive Symptoms in Bariatric Surgery Patients with Multiple Sclerosis. Obes Surg. 2018 Apr;28(4):1091-1097.

F. Quantification of patient and provider experience

Patient experience with PROMs:

• Lapin BR, Udeh B, Bautista JF, Katzan IL. Patient experience with patient-reported outcome measures in neurologic practice. Neurology. 2018 Sep 18;91(12):e1135-e1151. 

Provider experience with PROMs:

• Katzan IL, Thompson NR, Dunphy C, Urchek J, Lapin BR. Neurologic provider views on patient-reported outcomes including depression screening. Neurol Clin Pract. 2018 Apr;8(2):86-92.

Patient interest in health information technology:

• Featherall J, Lapin BR, Chaitoff A, Havele SA, Thompson N, Katzan I. Characterization of Patient Interest in Provider-Based Consumer Health Information Technology: Survey Study. J Med Internet Res. 2018 Apr 19;20(4):e128.