Research
Our research focuses on the development and application of novel statistical and machine learning methods in the field of medicine. Nowadays the unprecedented data in health care provide unique opportunities and challenges for scientific discovery through data analysis and mining, for which classical analytic methods often have limitations. We are particularly interested at the following areas: Integrative analysis of omics and imaging data Predictive modeling based on eletronic health records Synthetic data generation Design and conduct of clinical trials
Biography
Dr. Hu is a Full Staff Member in the Department of Quntitative Health Sicences and a Professor at the Lerner College of Medicine of Case Western Reserve University. He also serves as the Director of Scientific Affairs for the Center of Artificial Intelligence and Data Sciences of Pathology Institute at Cleveland Clinc.
Education & Professional Highlights
PhD in Statistics - University of Wisconsin-Madison
Madison, WI USA
2006
BS - Tsinghua University
Beijing, China
2001
Research
Our research focuses on the development and application of novel statistical and machine learning methods in the field of medicine. Nowadays the unprecedented data in health care provide unique opportunities and challenges for scientific discovery through data analysis and mining, for which classical analytic methods often have limitations. We are particularly interested at the following areas:
- Integrative analysis of omics and imaging data
- Predictive modeling based on eletronic health records
- Synthetic data generation
- Design and conduct of clinical trials
Our Team
Selected Publications
- Rashidi H, Albahra S, Robertson S, Tran N, Hu B. Common Statistical Concepts in the Supervised Machine Learning Arena. Frontiers in Oncology. 2023. In press.
- Hu B, Cha J, Fullerton JM, Hesam-Shariati S, Nakamura K, Nurnberger JI, Anand A. Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach. Transl Psychiatry. 2022 Apr 4;12(1):137.
- Rothberg MB, Hamilton A, Greene MT, Fox J, Lisheba O, Milinovich A, Gautier TN, Kim P, Kaatz S, Hu B. Derivation and Validation of a Risk Factor Model to Identify Medical Inpatients at Risk for Venous Thromboembolism. Thromb Haemost. 2022 Jul;122(7):1231-1238.
- Chen R, Aldred MA, Xu W, Zein J, Bazeley P, Comhair SAA, Meyers DA, Bleecker ER, Liu C, Erzurum SC, Hu B. Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA. Mitochondrion. 2021 May;58:303-310.
- Anand A, Nakamura K, Spielberg JM, Cha J, Karne H, Hu B. Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action. Transl Psychiatry. 2020 Apr 6;10(1):103.
- Li L, Greene T, Hu B(2018). A simple method to estimate the time-dependent receiver operating characteristic curve and the area under the curve with right censored data. Stat Methods Med Res. Aug;27(8):2264-2278.
- Bhasin JM, Hu B, Ting AH (2016). MethylAction: detecting differentially methylated regions that distinguish biological subtypes. Nucleic Acids Research44(1): 106-116.
- Hu B, Li L, Greene T (2016). Joint multiple imputation for longitudinal outcomes and clinical events that truncate longitudinal follow-up. Statistics in Medicine35(17): 2991-3006.