Andre Machado Lab | Lerner Research Institute

Principal Investigator

Andre Machado, MD, PhD

Staff
Chair, Neurological Institute
Location: Cleveland Clinic Main Campus

Research

The Andre Machado lab studies central nervous system plasticity and its role in stroke recovery, chronic pain and more.

Biography

Andre Machado, MD, PhD is the Chairman of the Neurological Institute and the Charles and Christine Carroll Family Endowed Chair in Functional Neurosurgery. Dr. Machado performs deep brain stimulation (DBS) surgery for patients with Parkinson’s disease, tremor, dystonia and obsessive-compulsive disorder as well as surgical procedures for patients with trigeminal neuralgia, intractable pain syndromes and spasticity.

Dr. Machado is a Professor of Neurosurgery at the Cleveland Clinic Lerner College of Medicine and has Joint Appointments in the Departments of Neuroscience and Biomedical Engineering. He is the past Chairman for the Joint Pain Section of the CNS/AANS and Vice-President of the American Society of Stereotactic and Functional Neurosurgery.

Dr. Machado is an Associate Chief of Staff at Cleveland Clinic and leads several enterprise-level projects with the Office of the Chief of Staff, including innovations in the model of care and a new program for professional career development.

Dr. Machado received his medical degree from the University of Sao Paulo in 1997. He completed his residency in the same institution in 2003 and obtained his PhD in 2004. He came to Cleveland Clinic in 2004, completed his fellowship in Stereotactic and Functional Neurosurgery in 2006 and has been on the staff at Cleveland Clinic since then.

Dr. Machado leads several deep brain stimulation and neuromodulation clinical trials as well as laboratory research. His research in deep brain stimulation for thalamic pain syndrome was awarded the National Institutes of Health Director’s New Innovator’s Award. His current research is aimed at developing novel treatments to promote rehabilitation after stroke and other acquired brain injuries and is funded by the NIH BRAIN initiative.

Education & Professional Highlights

Education & Fellowships

Fellowship - Cleveland Clinic
Functional Neurosurgery
Cleveland, OH USA
2006

Graduate School - University of Sao Paulo Faculty of Medicine
Sao Paulo,
2004

Residency - University of Sao Paulo Hospitals and Clinics
Neurosurgery
Sao Paulo,
2004

Internship - Universidade de Sao Paulo
Sao Paulo,
1998

Medical Education - University of Sao Paulo Faculty of Medicine
Sao Paulo,
1997

Awards & Honors

Gildenberg Award in Stereotactic and Functional Neurosurgery

Innovations & Patents

Preclinical research on deep-brain stimulation for rehabilitation of motor function following strokes
First randomized clinical trial of deep brain stimulation for thalmic pain syndrome
Research in new devices for deep brain stimulation
Research in new devices for neuromodulation, invasive and non-invasive
Emerging applications of deep brain stimulation including psychiatric disorders and traumatic brain injury
1. Intraluminal electrode assembly. US 7,532,938
2. Methods of treating medical conditions by neuromodulation of the cerebellar pathways. US 7,640,063
3. Methods of treating neurological conditions by neuromodulation of interhemispheric fibers. US 7,697,991
4. Corpus Callosum Neuromodulation Assembly. US 7,725,196
5. Method and system for treating acute heart failure by neuromodulation. US 8,818,501
6. Methods and systems of achieving hemodynamic control through neuromodulation. 20060100667
7. Systems and methods for neuromodulation using pre-recorded waveforms. 20080208284
8. Methods and apparatus for securing a neuromodulation lead to nervous system tissue or tissue surrounding the nervous system. 2009007644
9. Corpus Callosum Neuromodulation Method. US 8.942,812

Research

My research interests are in the fields of central nervous system plasticity and its implications in stroke rehabilitation, chronic pain and in movement disorders. We have performed translational research studies aimed at the development of novel therapies for stroke rehabilitation, in work funded by a National Institutes of Health award.

My clinical area of expertise is the neurosurgical management of patients with otherwise intractable pain syndromes and severe movement disorders such as Parkinson’s disease, dystonia and spasticity.

Our Team

Publications

Selected Publications

View publications for Andre Machado, MD, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Matias CM, Frizon LA, Nagel SJ, Lobel DA, Machado AG. (2018) Deep brain stimulation outcomes in patients implanted under general anesthesia with frame-based stereotaxy and intraoperative MRI. J Neurosurg. 129(6):1572-1578. PMID: 29372880

Chan HH, Cooperrider J, Chen Z, Gale JT, Baker KB, Wathen CA, Modic CR, Park HJ, Machado AG. (2018) Lateral Cerebellar Nucleus Stimulation has Selective Effects on Glutamatergic and GABAergic Perilesional Neurogenesis After Cortical Ischemia in the Rodent Model. Neurosurgery 83(5):1057-1067. PMID: 29029200

Gopalakrishnan R, Burgess RC, Malone DA, Lempka SF, Gale JT, Floden DP, Baker KB, Machado AG. (2018) Deep brain stimulation of the ventral striatal area for poststroke pain syndrome: a magnetoencephalography study. J Neurophysiol. 119(6):2118-2128. PMID: 29384450

Lempka SF, Malone DA, Hu B, Baker KB, Wyant A, Ozinga J, Plow EB, Pandya M, Kubu CS, Ford PJ, Machado AG. (2017) Randomized clinical trial of deep brain stimulation for post-stroke pain. Ann Neurol. 81(5):653-663. PMID: 28380672

Chan HH, Cooperrider JL, Park HJ, Wathen CA, Gale JT, Baker KB, Machado AG. (2017) Crossed Cerebellar Atrophy of the Lateral Cerebellar Nucleus in an Endothelin-1-Induced, Rodent Model of Ischemic Stroke. Front Aging Neurosci. 9:10. PMID: 28261086; PMCID: PMC5313508

Xiao R, Miller JA, Lubelski D, Alberts JL, Mroz TE, Benzel EC, Krishnaney AA, Machado AG. (2016) Quality of life outcomes following cervical decompression for coexisting Parkinson's disease and cervical spondylotic myelopathy. Spine J. 16(11):1358-1366. PMID: 27496286

Wathen C, Kshettry VR, Krishnaney A, Gordon SM, Fraser T, Benzel EC, Modic MT, Butler S, Machado AG. (2016)The Association Between Operating Room Personnel and Turnover With Surgical Site Infection in More Than 12 000 Neurosurgical Cases. Neurosurgery 79(6):889-894. PMID: 27465846

Gopalakrishnan R, Burgess RC, Plow EB, Floden DP, Machado AG. (2015) Early event related fields during visually evoked pain anticipation. Clin Neurophysiol. pii: S1388-2457(15)01121-9. PMID:26733321; PMCID: PMC4753121

Cooperrider J, Gale JT, Gopalakrishnan R, Chan HH, Wathen C, Park HJ, Baker KB, Shaikh AG, Machado AG. (2015) Differential frequency modulation of neural activity in the lateral cerebellar nucleus in failed and successful grasps. Exp Neurol. 277:27-34. PMID: 26698925; PMCID: PMC4761293

Cunningham DA, Potter-Baker KA, Knutson JS, Sankarasubramanian V, Machado AG, Plow EB. (2015) Tailoring Brain Stimulation to the Nature of Rehabilitative Therapies in Stroke: A Conceptual Framework Based on their Unique Mechanisms of Recovery. Phys Med Rehabil Clin N Am. 26(4):759-74. PMID: 26522911; PMCID: PMC4630680

Park HJ, Furmaga H, Cooperrider J, Gale JT, Baker KB, Machado AG. (2015) Modulation of Cortical Motor Evoked Potential After Stroke During Electrical Stimulation of the Lateral Cerebellar Nucleus. Brain Stimul. 8(6):1043-8. PMID: 26215752; PMCID: PMC4656069

Gopalakrishnan R, Burgess RC, Plow EB, Floden DP, Machado AG. (2015) A magnetoencephalography study of multi-modal processing of pain anticipation in primary sensory cortices. Neuroscience 304:176-89. PMID: 26210576; PMCID: PMC4547876

Floden D, Busch RM, Cooper SE, Kubu CS, Machado AG. (2015) Global cognitive scores do not predict outcome after subthalamic nucleus deep brain stimulation. Mov Disord. 30(9):1279-83. PMID: 26175227

Lempka SF, McIntyre CC, Kilgore KL, Machado AG. (2015) Computational analysis of kilohertz frequency spinal cord stimulation for chronic pain management. Anesthesiology 122(6):1362-76. PMID: 25822589

Matias CM, Mehanna R, Cooper SE, Amit A, Lempka SF, Silva D, Carlotti CG Jr, Butler RS, Machado AG. (2015) Correlation among anatomic landmarks, location of subthalamic deep brain stimulation electrodes, stimulation parameters, and side effects during programming monopolar review. Neurosurgery 11 Suppl 2:99-108; discussion 108-9. PMID: 25599207

Floden D, Cooper SE, Griffith SD, Machado AG. (2014) Predicting quality of life outcomes after subthalamic nucleus deep brain stimulation. Neurology 83(18):1627-33. PMID: 25274851; PMCID: PMC4223084

Nagel SJ, Lempka SF, Machado AG. (2014) Percutaneous spinal cord stimulation for chronic pain: indications and patient selection. Neurosurg Clin N Am. 25(4):723-33. PMID: 25240659

Cooperrider J, Furmaga H, Plow E, Park HJ, Chen Z, Kidd G, Baker KB, Gale JT, Machado AG. (2014) Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent model. J Neurosci. 34(27):9040-50. PMID: 24990924; PMCID: PMC4078081

Matias CM, Amit A, Lempka SF, Ozinga JG 4th, Nagel SJ, Lobel DA, Machado AG. (2014) Long-term outcomes after replacement of percutaneous leads with paddle leads in a retrospective cohort of patients with spinal cord stimulation systems. Neurosurgery. 75(4):430-6; discussion 436. PMID: 24983442

Furmaga H, Park HJ, Cooperrider J, Baker KB, Johnson M, Gale JT, Machado AG. (2014) Effects of ketamine and propofol on motor evoked potentials elicited by intracranial microstimulation during deep brain stimulation. Front Syst Neurosci. 8:89. PMID: 24904312; PMCID: PMC4033249

Machado AG, Gopalakrishnan R, Plow EB, Burgess RC, Mosher JC. (2014) A magnetoencephalography study of visual processing of pain anticipation. J Neurophysiol. 112(2):276-86. PMID: 24790165; PMCID: PMC4064417

Kelly ML, Malone D, Okun MS, Booth J, Machado AG. (2014) Barriers to investigator-initiated deep brain stimulation and device research. Neurology 82(16):1465-73. PMID: 24670888; PMCID: PMC4001198

Careers

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