Ken Baker Laboratory

Research

Overview

My research interests are in the areas of neuromodulation, in particular the application of neurostimulation-based approaches for the study and treatment of neurological and psychiatric disease. I am currently involved in studies of the neurophysiology of movement disorders, the therapeutic mechanisms of deep brain stimulation (DBS), and the potential of novel DBS approaches to improve treatment efficacy and outcomes in both Parkinson’s disease and stroke. My work involves experimental and clinical trial research in humans as well as preclinical trials using non-human animal models of disease. Many of my projects involve close collaboration with other neuroscientists as well as neurosurgeons, neurologists, radiologists, and/or biomedical engineers.     

Selected Publications

Selected Publications (2014 - present):

Chornyy S, Das A, Borovicka JA, Patel D, Chan HH, Hermann JK, Jaramillo TC, Machado AG, Baker KB, Dana H. (2021) Cellular-resolution monitoring of ischemic stroke pathologies in the rat cortex. Biomed Opt Express 16;12(8):4901-4919. PMID: 34513232; PMCID: PMC8407830

Campbell BA, Cho H, Faulhammer RM, Hogue O, Tsai JP, Hussain MS, Machado AG, Baker KB. (2021) Stability and Effect of Parkinsonian State on Deep Brain Stimulation Cortical Evoked Potentials. Neuromodulation 2021 Jul 26. doi: 10.1111/ner.13508. PMID: 34309115

Cooperrider J, Momin A, Baker KB, Machado AG. (2021) Cerebellar Neuromodulation for Stroke. Curr Phys Med Rehabil Rep. 8(2):57-63. PMID: 33585074; PMCID: PMC7879492

Bore JC, Campbell BA, Cho H, Gopalakrishnan R, Machado AG, Baker KB. (2020) Prediction of mild parkinsonism revealed by neural oscillatory changes and machine learning. J Neurophysiol. 124(6):1698-1705. PMID: 33052766; PMCID: PMC7814907

Jones SE, Lempka SF, Gopalakrishnan R, Baker KB, Beall EB, Bhattacharyya P, Huang X, Lin J, Chen J, Lowe MJ, Malone DA, Machado AG. (2021) Functional Magnetic Resonance Imaging Correlates of Ventral Striatal Deep Brain Stimulation for Poststroke Pain. Neuromodulation 24(2):259-264. PMID: 32744789

Branco de Paiva F, Campbell BA, Frizon LA, Martin A, Maldonado-Naranjo A, Machado AG, Baker KB. (2020) Feasibility and performance of a frameless stereotactic system for targeting subcortical nuclei in nonhuman primates. J Neurosurg. Mar 6:1-8. PMID: 32114536

Frizon LA, Gopalakrishnan R, Hogue O, Floden D, Nagel SJ, Baker KB, Isolan GR, Stefani MA, Machado AG. (2020) Cortical thickness in visuo-motor areas is related to motor outcomes after STN DBS for Parkinson's disease. Parkinsonism Relat Disord. 71:17-22. PMID: 31978672

Campbell BA, Machado AG, Baker KB. (2019) Electrophysiologic mapping for deep brain stimulation for movement disorders. Handb Clin Neurol.160:345-355. PMID: 31277859

Cooperrider J, Chan HH, Gale JT, Park HJ, Baker KB, Machado AG. (2019) BrdU-induced hyperlocomotion in the stroked rat. Neurosci Lett.703:96-98. PMID: 30853407; PMCID: PMC6525031

Chan HH, Wathen CA, Mathews ND, Hogue O, Modic JP, Kundalia R, Wyant C, Park HJ, Najm IM, Trapp BD, Machado AG, Baker KB. (2018) Lateral cerebellar nucleus stimulation promotes motor recovery and suppresses neuroinflammation in a fluid percussion injury rodent model. Brain Stimul. 11(6):1356-1367. PMID: 30061053

Hendrix CM, Campbell BA, Tittle BJ, Johnson LA, Baker KB, Johnson MD, Molnar GF, Vitek JL. (2018) Predictive encoding of motor behavior in the supplementary motor area is disrupted in Parkinsonism. J Neurophysiol. 120(3):1247-1255. PMID: 29873615

Gopalakrishnan R, Burgess RC, Malone DA, Lempka SF, Gale JT, Floden DP, Baker KB, Machado AG. (2018) Deep brain stimulation of the ventral striatal area for poststroke pain syndrome: a magnetoencephalography study. J Neurophysiol. 119(6):2118-2128. PMID: 29384450

Hashimoto T, Muralidharan A, Yoshida K, Goto T, Yako T, Baker KB, Vitek JL. (2017) Neuronal activity and outcomes from thalamic surgery for spinocerebellar ataxia. Ann Clin Transl Neurol. 5(1):52-63. PMID: 29376092; PMCID: PMC5771317

Chan HH, Cooperrider J, Chen Z, Gale JT, Baker KB, Wathen CA, Modic CR, Park HJ, Machado AG. (2017) Lateral Cerebellar Nucleus Stimulation has Selective Effects on Glutamatergic and GABAergic Perilesional Neurogenesis After Cortical Ischemia in the Rodent Model. Neurosurgery 83(5):1057-1067. PMID: 29029200

Escobar Sanabria D, Johnson LA, Nebeck SD, Zhang J, Johnson MD, Baker KB, Molnar GF, Vitek JL. (2017) Parkinsonism and vigilance: alteration in neural oscillatory activity and phase-amplitude coupling in the basal ganglia and motor cortex. J Neurophysiol. 118(5):2654-2669. PMID: 28835526; PMCID: PMC5672540

Lempka SF, Malone DA, Hu B, Baker KB, Wyant A, Ozinga J, Plow EB, Pandya M, Kubu CS, Ford PJ, Machado AG. (2017) Randomized clinical trial of deep brain stimulation for post-stroke pain. Ann Neurol. 81(5):653-663. PMID: 28380672

Wang J, Johnson LA, Jensen AL, Baker KB, Vitek JL. (2017) Network wide oscillations in the parkinsonian state: Alterations in neuronal activities occur in the premotor cortex in parkinsonian non-human primates. J Neurophysiol. 117(6):2242-2249. PMID: 28228579

Chan HH, Cooperrider JL, Park HJ, Wathen CA, Gale JT, Baker KB, Machado AG. (2017) Crossed Cerebellar Atrophy of the Lateral Cerebellar Nucleus in an Endothelin-1-Induced, Rodent Model of Ischemic Stroke. Front Aging Neurosci. 9:10. PMID: 28261086; PMCID: PMC5313508

Muralidharan A, Zhang J, Ghosh D, Johnson MD, Baker KB, Vitek JL. (2017) Modulation of Neuronal Activity in the Motor Thalamus during GPi-DBS in the MPTP Nonhuman Primate Model of Parkinson's Disease. Brain Stimul. 10(1):126-138. PMID: 27839724; PMCID: PMC5241168

Johnson LA, Nebeck SD, Muralidharan A, Johnson MD, Baker KB, Vitek JL. (2016) Closed-Loop Deep Brain Stimulation Effects on Parkinsonian Motor Symptoms in a Non-Human Primate - Is Beta Enough? Brain Stimul. 9(6):892-896. PMID: 27401045; PMCID: PMC5143196

Wang J, Nebeck S, Muralidharan A, Johnson MD, Vitek JL, Baker KB. (2016) Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Non-Human Primate Model of Parkinsonism. Brain Stimul. 9(4):609-617. PMID: 27151601

Muralidharan A, Jensen AL, Connolly AT, Hendrix CM, Johnson MD, Baker KB, Vitek JL. (2016) Physiological changes in the pallidum in a progressive model of Parkinson's disease: Are oscillations enough? Exp Neurol. 279:187-196. PMID: 26946223; PMCID: PMC4920549

Cooperrider J, Gale JT, Gopalakrishnan R, Chan HH, Wathen C, Park HJ, Baker KB, Shaikh AG, Machado AG. (2016) Differential frequency modulation of neural activity in the lateral cerebellar nucleus in failed and successful grasps. Exp Neurol. 277:27-34. PMID: 26698925; PMCID: PMC4761293

Connolly AT, Vetter RJ, Hetke JF, Teplitzky BA, Kipke DR, Pellinen DS, Anderson DJ, Baker KB, Vitek JL, Johnson MD. (2016) A Novel Lead Design for Modulation and Sensing of Deep Brain Structures. IEEE TBME 63(1):148-57. PMID: 26529747; PMCID: PMC4716872

Connolly AT, Muralidharan A, Hendrix C, Johnson L, Gupta R, Stanslaski S, Denison T, Baker KB, Vitek JL, Johnson MD. (2015) Local field potential recordings in a non-human primate model of Parkinsons disease using the Activa PC + S neurostimulator. J Neurosci. 12(6):066012. PMID: 26469737; PMCID: PMC5130227

Dorval AD, Murali A, Jensen AL, Baker KB, Vitek JL. (2015) Information in pallidal neurons increases with parkinsonian severity. Parkinsonism Relat Disord. 21(11):1355-61. PMID: 26433544; PMCID: PMC4631644

Park HJ, Furmaga H, Cooperrider J, Gale JT, Baker KB, Machado AG. (2015) Modulation of Cortical Motor Evoked Potential After Stroke During Electrical Stimulation of the Lateral Cerebellar Nucleus. Brain Stimul. 8(6):1043-8. PMID: 26215752; PMCID: PMC4656069

Zitella LM, Teplitzky BA, Yager P, Hudson HM, Brintz K, Duchin Y, Harel N, Vitek JL, Baker KB, Johnson MD. (2015) Subject-specific computational modeling of DBS in the PPTg area. Front Comp Neurosci. 9:93. PMID: 26236229; PMCID: PMC4500924

Agnesi F, Muralidharan A, Baker KB, Vitek JL, Johnson MD. (2015) Fidelity of frequency and phase entrainment of circuit-level spike activity during DBS. J Neurophysiol. 114(2):825-34. PMID: 26084905; PMCID: PMC4533062

Zitella LM, Xiao Y, Teplitzky BA, Kast DJ, Duchin Y, Baker KB, Vitek JL, Adriany G, Yacoub E, Harel N, Johnson MD. (2015) In Vivo 7T MRI of the Non-Human Primate Brainstem. PLoS One 10(5):e0127049. PMID: 25965401; PMCID: PMC4428864

Connolly AT, Jensen AL, Baker KB, Vitek JL, Johnson MD. (2015) Classification of pallidal oscillations with increasing parkinsonian severity. J Neurophysiol. 114(1):209-18. PMID: 25878156; PMCID: PMC4507953

Connolly A, Jensen A, Bello E, Netoff T, Baker KB, Johnson M, Vitek JL. (2015) Modulations in oscillatory frequency and coupling in globus pallidus with increasing parkinsonian severity. J Neurosci. 35(15):6231-6240. PMID: 25878293; PMCID: PMC4397612

Johnson LA, Xu W, Baker KB, Zhang J, Vitek JL. (2015) Modulation of motor cortex neuronal activity and motor behavior during subthalamic nucleus stimulation in the normal primate. J Neurophys. 113(7):2549-2554. PMID: 25673744; PMCID: PMC4416594

Cooperrider J, Furmaga H, Plow E, Park H, Chen Z, Kidd G, Baker KB, Gale J, Machado AG. (2014) Chronic deep cerebellar stimulation promotes long-term potentiation, microstructural plasticity, and reorganization of perilesional cortical representation in a rodent model. J Neurosci. 34(27):9040-50. PMID: 24990924; PMCID: PMC4078081

Furmaga H, Park Hyun-Joo, Cooperrider J, Baker KB, Johnson M, Gale JT, Machado AG. (2014) Effects of ketamine and propofol on motor evoked potentials elicited by intracranial microstimulation during deep brain stimulation. Front Syst Neurosci. 8:1-9. PMID: 24904312; PMCID: PMC4033249

John K. Hermann, Ashley Borseth, Francesco G. Pucci, Carmen Toth, Olivia Hogue, Hugh H. Chan, Andre G. Machado, Kenneth B. Baker, Changes in somatosensory evoked potentials elicited by lateral cerebellar nucleus deep brain stimulation in the naïve rodent, Neuroscience Letters, Volume 786, 2022, 136800, ISSN 0304-3940.

Campbell BA, Favi Bocca L, Escobar DS, Almeida J, Rammo R, Nagel S, Machado AG, Baker KB. The impact of pulse timing on cortical and subthalamic nucleus deep brain stimulation evoked potentials. Front. Hum. Neurosci. 2022 Sep 20. 16:1009223. doi: 10.3389/fnhum.2022.1009223.

Gopalakrishnan R, Cunningham DA, Hogue O, Schroedel M, Campbell BA, Plow EB, Baker KB, Machado AG. Cortico-cerebellar connectivity underlying motor control in chronic post-stroke individuals. J Neurosci. 2022 May 23:JN-RM-2443-21. doi: 10.1523/JNEUROSCI.2443-  21.2022. Epub ahead of print. PMID: 35610051.

Chelangat Bore J, A Campbell B, Cho H, Pucci F, Gopalakrishnan R, G Machado A, B Baker K. Long-lasting effects of subthalamic nucleus coordinated reset deep brain stimulation in the non-human primate model of parkinsonism: A case report. Brain Stimul. 2022 Apr 8;15(3):598-600. doi: 10.1016/j.brs.2022.04.005. Epub ahead of print. PMID: 35405326.

Bore JC, Toth C, Campbell BA, Cho H, Pucci F, Hogue O, Machado AG, Baker KB. Consistent Changes in Cortico-Subthalamic Directed Connectivity Are Associated With the Induction of Parkinsonism in a Chronically Recorded Non-human Primate Model. Front Neurosci. 2022 Mar 4;16:831055. doi: 10.3389/fnins.2022.831055. PMID: 35310095; PMCID: PMC8930827.

Campbell BA, Cho H, Faulhammer RM, Hogue O, Tsai JP, Hussain MS, Machado AG, Baker KB. Stability and Effect of Parkinsonian State on Deep Brain Stimulation Cortical Evoked Potentials. Neuromodulation. 2021 Jul 26. doi: 10.1111/ner.13508. Epub ahead of print. PMID: 34309115.

Bore J, Campbell BA, Cho H., Gopalakrishnan R, Machado AG, Baker KB. Prediction of mild Parkinsonism revealed by neural oscillatory changes and machine learning. J Neurophysiol. 2020 Oct 14. doi: 10.1152/jn.00534.2020. Epub ahead of print. PMID: 33052766.

Branco de Paiva F*, Campbell BA*, Frizon LA, Martin A, Maldonado-Naranjo A, Machado AG, Baker KB. Feasibility and performance of a frameless stereotactic system for targeting subcortical nuclei in nonhuman primates. J Neurosurg. 2020 Mar 6:1-8. doi: 0.3171/2019.12.JNS192946. Epub ahead of print. PMID: 32114536. (*authors contributed equally to this manuscript).