Research

Recent Inflammation & Immunity Publications

Adaptive Immunity

A CD6-targeted antibody-drug conjugate as a potential therapy for T cell-mediated disorders. Zhang L, Luo L, Chen JY, Singh R, Baldwin Iii WM, Fox DA, Lindner DJ, Martin DF, Caspi RR, Lin F.JCI Insight. 2023 Nov 2:e172914. doi: 10.1172/jci.insight.172914. Online ahead of print. PMID: 37917882

Cancer Immunology

CD6-targeted antibody-drug conjugate as a new therapeutic agent for T cell lymphoma.  Parameswaran N, Luo L, Zhang L, Chen J, DiFilippo FP, Androjna C, Fox DA, Ondrejka SL, Hsi ED, Jagadeesh D, Lindner DJ, Lin F. Leukemia. 2023 Oct;37(10):2050-2057. doi: 10.1038/s41375-023-01997-8. Epub 2023 Aug 12. PMID: 37573404

Inflammation & Fibrosis

Single-cell isolation from full-thickness human intestinal tissue resections for single-cell RNA sequencing. West GA, Zhao S, Nguyen QT, Christensen SM, Gordon IO, Holubar SD, Kravarik KM, Fiocchi C, Mukherjee PK, Rieder F. STAR Protoc. 2023 Nov 3;4(4):102686. doi: 10.1016/j.xpro.2023.102686. PMID: 37925636

Challenges in and Opportunities for Electronic Health Record-Based Data Analysis and Interpretation. Kim MK, Rouphael C, McMichael J, Welch N, Dasarathy S.Gut Liver. 2023 Oct 31. doi: 10.5009/gnl230272. PMID: 37905424 Review

Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats. Xu J, Huang P, Bie B, Dai Y, Ben-Salem S, Borjini N, Zhang L, Chen J, Olman M, Cheng J, Lin F. J Immunol. 2023 Oct 20:ji2300252. doi: 10.4049/jimmunol.2300252. Online ahead of print.PMID: 37861348

D-2-hydroxyglutarate regulates human brain vascular endothelial cell proliferation and barrier function. Cao C, Zhang L, Sorensen MD, Reifenberger G, Kristensen BW, McIntyre TM, Lin F.J Neuropathol Exp Neurol. 2023 Oct 20;82(11):921-933. doi: 10.1093/jnen/nlad072. PMID: 37740942

Local Inflammation but not Kidney Cell Infection Associated with High APOL1 Expression in COVID-Associated Nephropathy. Nguyen JK, Wu Z, Agudelo J, Herlitz LC, Miller AW, Bruggeman LA. Kidney360. 2023 Nov 6. doi: 10.34067/KID.0000000000000290. PMID: 37927001

Hematopoietic stem cells and extramedullary hematopoiesis in the lungs. Reichard A, Wanner N, Farha S, Asosingh K. Cytometry A. 2023 Oct 9. doi: 10.1002/cyto.a.24804. PMID: 37807901 Review

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury. Varadharajan V, Ramachandiran L, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Guilshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. bioRxiv. 2023 Sep 27:2023.09.26.559533. doi: 10.1101/2023.09.26.559533 

Mucosal Biology & Epithelial Barriers

Select symbionts drive high IgA levels in the mouse intestine. Zhang S, Han Y, Schofield W, Nicosia M, Karell PE, Newhall KP, Zhou JY, Musich RJ, Pan S, Valujskikh A, Sangwan N, Dwidar M, Lu Q, Stappenbeck TS. Cell Host Microbe. 2023 Oct 11;31(10):1620-1638.e7. doi: 10.1016/j.chom.2023.09.001. Epub 2023 Sep 29. PMID: 37776865

Modelling host–microbiome interactions in organ-on-a-chip platforms. Yong Cheol Shin, Nam Than, Soyoun Min, Woojung Shin, Hyun Jung Kim Review Article. Published: 17 November 2023 Nature Reviews Bioengineering (2023) Abstract

Electronic cigarette exposure disrupts airway epithelial barrier function and exacerbates viral infection. Raduka A, Gao N, Chatburn RL, Rezaee F.Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L580-L593. doi: 10.1152/ajplung.00135.2023. Epub 2023 Sep 12. PMID: 37698113

Signaling & Metabolic Networks

Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation. Jia J, Arif A, Willard B, Smith JD, Stuehr DJ, Hazen SL, Fox PL. Mol Cell. 2023 Nov 2;83(21):3941. doi: 10.1016/j.molcel.2023.10.014. PMID: 37922873

A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution. Dennis J Stuehr, Pranjal Biswas, Yue Dai, Arnab Ghosh, Sidra Islam,Dhanya Thamaraparambil Jayaram  Bioessays. 2023 Aug;45(8):e2300055. doi: 10.1002/bies.202300055. Epub 2023 Jun 5. PMID: 37276366PMCID: PMC10478511 DOI:>10.1002/bies.202300055

CD6 triggers actomyosin cytoskeleton remodeling after binding to its receptor complex. Borjini N, Lun Y, Jang GF, Crabb J, Chen Y, Crabb J, Fox DA, Ivanov AI, Lin F. J Leukoc Biol. 2023 Oct 11:qiad124. doi: 10.1093/jleuko/qiad124. Online ahead of print. PMID: 37820034

Interferon induction by STING requires its translocation to the late endosomes. Wang C, Sharma N, Kessler PM, Sen GC. Traffic. 2023 Dec;24(12):576-586. doi: 10.1111/tra.12918. Epub 2023 Sep 2. PMID: 3765879

Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease. Mrdjen M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain CJ, Mitchell M, Radaeva S, Barton B, Szabo G, Dasarathy S, Wang Z, Hazen SL, Brown JM, Nagy LE. Hepatol Commun. 2023 Oct 12;7(11):e0284. doi: 10.1097/HC9.0000000000000284. eCollection 2023 Nov 1. PMID: 37820283

Exhaled Breath Analysis Using Selected Ion Flow Tube Mass Spectrometry and Disease Severity in Heart Failure. Tang WHW, Tranchito L, Albert C, Gul ZG, Cikach FS Jr, Grove D, Wu Y, Dweik RA. Metabolites. 2023 Oct 3;13(10):1049. doi: 10.3390/metabo13101049.PMID: 37887374

Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease. Mrdjen M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain CJ, Mitchell M, Radaeva S, Barton B, Szabo G, Dasarathy S, Wang Z, Hazen SL, Brown JM, Nagy LE. Hepatol Commun. 2023 Oct 12;7(11):e0284. doi: 10.1097/HC9.0000000000000284. eCollection 2023 Nov 1. PMID: 37820283

Transplant Immunology

Mitochondrial injury during normothermic regional perfusion (NRP) and hypothermic oxygenated perfusion (HOPE) in a rodent model of DCD liver transplantation. Panconesi R, Carvalho MF, Eden J, Fazi M, Ansari F, Mancina L, Navari N, Sousa Da Silva RX, Dondossola D, Borrego LB, Pietzke M, Peris A, Meierhofer D, Muiesan P, Galkin A, Marra F, Dutkowski P, Schlegel A. EBioMedicine. 2023 Nov 2;98:104861. doi: 10.1016/j.ebiom.2023.104861. PMID: 37924707

Reply: Acute rejection after liver transplantation with machine perfusion versus static cold storage: A systematic review and meta-analysis. Maspero M, Hashimoto K, Fairchild RL, Schlegel A.Hepatology. 2023 Oct 9. doi: 10.1097/HEP.0000000000000630. PMID: 37812462

The role of ischaemia-reperfusion injury and liver regeneration in hepatic tumour recurrence. Maspero M, Yilmaz S, Cazzaniga B, Raj R, Ali K, Mazzaferro V, Schlegel A. JHEP Rep. 2023 Jul 11;5(11):100846. doi: 10.1016/j.jhepr.2023.100846. eCollection 2023 Nov.PMID: 37771368 Review