Srinivasan Dasarathy, MD
Staff
Location: Cleveland Clinic Main Campus
Research
Biography
Dr. Dasarathy's primary interest is in the management of patients waiting for liver transplantation and during the post--liver-transplant period. He has a special interest in the treatment of non-alcoholic fatty liver disease.
Dr. Dasarathy serves on the Educational Committee of the American Association of the Study of Liver Diseases.
Education & Professional Highlights
Education & Fellowships
Residency - MetroHealth Medical Center
Medicine
Cleveland, OH USA
1999
Fellowship - MetroHealth Medical Center
Gastroenterology
Cleveland, OH USA
1998
Internship - All India Institute of Medical Sciences
Gastroenterology
New Delhi, India
1989
Medical Education - Jawaharlal Institute of Post Graduate Medical Education and Research
Pondicherry, India,
1984
Certifications
- Internal Medicine - Gastroenterology
Awards & Honors
- Peter Adams Award for Clinical Research, 1999
Research
Our research program consists of a robust clinical, translational, and fundamental laboratory-based research that focuses on the skeletal muscle metabolic responses during chronic diseases including liver disease. Muscle loss is consistently observed in patients with chronic liver disease and other end stage organ diseases and adversely affects clinical outcomes.
Our team has identified unique cellular stress responses mediated by hyperammonemia, hypoxia and ethanol exposure as mediators of translational regulation and subcellular organelle dysfunction that contribute to muscle loss in disease. Our discoveries include the development of accelerated senescence in response to chronic cellular stress.
We use complementary state of the art approaches including integrated metabolic-molecular experimental studies, multiomics analyses and genome association studies in a comprehensive array cellular and rodent models as well as human disease subjects to dissect molecular regulation of metabolic plasticity in chronic diseases.
These studies have broad clinical applications because they lay the foundation for developing novel, mechanism-based targeted therapies to restore protein homeostasis and molecular and metabolic perturbations in chronic diseases.
Our Team
Selected Publications
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