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Olumuyiwa Awoniyi Laboratory

❮Inflammation & Immunity Olumuyiwa Awoniyi Laboratory
  • Olumuyiwa Awoniyi Laboratory
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Principal Investigator

 Olumuyiwa Awoniyi Headshot

Olumuyiwa Awoniyi, MD, PhD

Associate Staff
Email: [email protected]
Location: Cleveland Clinic Main Campus

Research

Innovating Microbial-Based Solutions for Hepatobiliary and Digestive Health

At the forefront of gastroenterology and hepatology, the Olumuyiwa Awoniyi lab endeavors to unlock the microbial mysteries intertwined with primary sclerosing cholangitis (PSC) and inflammatory bowel diseases (IBD). Our goal is to illuminate the microbial-host dialogues and intestinal-hepatobiliary interplay, paving the way for groundbreaking diagnostics and therapies. Fueled by a passion for clinical excellence and scientific discovery, we are committed to refining the management of these challenging conditions, with a vision to attenuate disease progression and enhance patient care. 


Biography

Coming soon. 


Education & Professional Highlights

Appointed
2022

Education & Fellowships

Fellowship - University of North Carolina
Transplant Hepatology
Chapel Hill, NC USA
2022

Fellowship - University of North Carolina
Gastroenterology/Hepatology
Chapel Hill, NC USA
2021

Residency - The University of Michigan Health System
Internal Medicine
Ann Arbor, MI USA
2016

Internship - The University of Michigan Health System
Internal Medicine
Ann Arbor, MI USA
2014

Medical Education - University of Washington School of Med.
Seattle, WA USA
2013

Graduate School - University of Washington School of Med.
Molecular and Cellular Biology
Seattle, WA USA
2012

Undergraduate - Beloit College
Biochemistry
Beloit, WI USA
2003

Research

Research

Innovating Microbial-Based Solutions for Hepatobiliary and Digestive Health

At the forefront of gastroenterology and hepatology, my research endeavors to unlock the microbial mysteries intertwined with primary sclerosing cholangitis (PSC) and inflammatory bowel diseases (IBD). My goal is to illuminate the microbial-host dialogues and intestinal-hepatobiliary interplay, paving the way for groundbreaking diagnostics and therapies. Fueled by a passion for clinical excellence and scientific discovery, I am committed to refining the management of these challenging conditions, with a vision to attenuate disease progression and enhance patient care.

Through my research, I seek to:

Decipher the Microbial Language: Understanding how specific microbes and their metabolites influence hepatobiliary disorders.

Advance Microbial Therapeutics: Developing microbial-based interventions to reduce the burden of liver fibrosis in PSC.

Illuminate Carcinogenic Pathways: Investigating the hepatobiliary influence on colorectal carcinogenesis within the PSC-IBD context.

Shape Clinical Outcomes: Aiming for a paradigm shift in how we perceive and treat PSC-IBD, informed by an innovative bi-compartmental disease model. With the ultimate aspiration of becoming an independently funded physician-scientist, my quest is to contribute significant insights into the etiology of PSC and its intricate association with IBD, ultimately influencing clinical outcomes and providing hope for patients worldwide.

Our Team

Our Team

Publications

Selected Publications

View publications for Olumuyiwa Awoniyi, MD, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)


Careers

Careers

Postdoctoral Fellowship Opportunity  - Olumuyiwa Awoniyi Lab

Title: Postdoctoral Research Associate in Microbe-Host Interactions and Cholestatic Liver Diseases  

Overview: The Lerner Research Institute at Cleveland Clinic invites applications for a Postdoctoral Research Associate position within the Department of Inflammation and Immunity. This position, under the mentorship of Dr. (Olu)Muyiwa Awoniyi, focuses on the pathophysiology of cholestatic liver diseases and the interplay between gut microbiota and host health. The successful candidate will be engaged in high-impact translational research, contributing to a deeper understanding of Primary Sclerosing Cholangitis (PSC) and its associated risks.  

Research Focus: The selected applicant will join the Awoniyi lab, which is at the forefront of investigating the role of the gut microbiome in PSC and its correlation with Inflammatory Bowel Disease (IBD), as well as the predisposition to hepatobiliary and colorectal cancer. Our research strategy integrates patient-derived clinical data with in vitro and in vivo experimental models, aiming to: Explore the therapeutic potential of microbial strains in PSC, aiming to identify bacteria that may mitigate disease symptoms or modify its course. Investigate the microbial driven therapeutic and pathogenic mechanisms of colitis-associated colorectal dysplasia in PSC-IBD models, examining microbial, intestinal mucosa and biliary contributors to disease progression. Assess the effects of fecal microbial transplants from PSC patients on biliary health in germ-free mice, to understand the microbiome's influence on disease development.  

Responsibilities: The Postdoctoral Research Fellow will contribute to our dynamic research environment by: Designing and conducting experiments. Analyzing data and preparing manuscripts for peer-reviewed journals. Pursuing extramural funding opportunities, including fellowships. Disseminating findings via conference presentations and scientific publications. Collaborating within multidisciplinary teams to expand the scope of research  

Requirements: Applicants must have completed a terminal degree (D.V.M., M.D., Ph.D.) in a relevant scientific discipline such as hepatology, biochemistry, immunology, microbiology, or molecular biology. Candidates should have an established track record of research excellence as evidenced by peer-reviewed publications. Proficiency in English and strong communication skills are essential. While prior experience with rodent models of liver disease is advantageous, outstanding candidates without specific experience in this field are also encouraged to apply.  

Application Submission: Interested candidates should email their curriculum vitae (CV) and contact information for three professional references to Dr. (Olu)Muyiwa Awoniyi at [email protected].  

Equal Opportunity Statement: Cleveland Clinic is committed to principles of diversity and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Our campus is a smoke-free and drug-free workplace.   


Training at Lerner Research Institute

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