The Aronica lab investigates the role of several components of the extracellular matrix (ECM) in the development and pathogenesis of asthma.
Mark Aronica, MD, is a Staff Member of the Department of Pulmonary, Allergy and Critical Care Medicine, as well as the Department of Pathobiology. His specialty interests include asthma and allergic disorders.
Dr. Aronica is an Assistant Professor in the Department of Molecular Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University in Cleveland, Oh. He is board certified in internal medicine, pulmonary medicine and allergy and immunology.
He earned his medical degree from the State University of New York at Buffalo School of Medicine, Buffalo, NY. He completed a residency at the University of Pittsburgh Medical Center in Pittsburgh, Penn., and postdoctoral fellowships in allergy, pulmonary and critical care medicine at Vanderbilt University Hospital in NasHVTIlle, Tenn.
He is a member of the American Thoracic Society and the American Academy of Allergy, Asthma and Immunology.
He has published a number of articles on topics such as allergic airway disease, steroids and asthma, and allergic lung disease, among many others.
Education & Fellowships
Fellowship - Vanderbilt University Hospital
Allergy/Immunology
Nashville, TN USA
2001
Fellowship - Vanderbilt University Hospital
Pulmonary & Critical Care Medi
Nashville, TN USA
1997
Residency - University of Pittsburgh Medical Center & Children's Hospital of Pittsburgh
Internal Medicine
Pittsburgh, PA USA
1994
Medical Education - State University of New York at Buffalo School of Medicine
Buffalo, NY USA
1991
Certifications
Awards & Honors
Asthma, an epidemic that affects more than 155 million people in the world, is a chronic disease characterized by exacerbations and progressive loss of lung function. Despite the field’s understanding of asthma as an inflammatory disease and the mechanisms that drive and initiate inflammation, little is known about the mechanisms related to resolution of inflammation or its impact on lung function and structural changes. The Aronica lab investigates the role of several components of the extracellular matrix (ECM) in the development and pathogenesis of asthma.
Specific areas of study in the Aronica lab include:
These studies will help to determine the distribution and changes in matrix composition in the airways and if these changes are permanent or resolve after antigen withdrawal and resolution of inflammation, as well as providing insight into the mechanisms by which hyaluronan is synthesized and degraded in the airway.
The lab’s long-term goal is to define mechanisms that regulate the synthesis, degradation and organization of hyaluronan, TSG-6 and IaI within the lung, how these matrix components affect inflammation and their effects on lung structure and function.
View publications for Mark Aronica, MD
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-Asosingh K, Hanson JD, Cheng G, Aronica MA, Erzurum SC. Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia. J Allergy Clin Immunol. 2010 Apr;125(4):918-25. Epub 2010 Mar 15.
-Zhu, L., Zhuo, L., Kimata, K., Yamaguchi, E., Watanabe, H., Aronica, M.A., Hascall, V.C., and Baba, K.. Deficiency of the SHAP-hyaluronan Complex Enhances Airway Hyperresponsiveness in a Murine Model of Asthma. Int Arch Allergy Immunol. May 18;153(3):223-233, 2010.
-Cheng G, Swaidani S, Sharma M, Lauer ME, Hascall VC, Aronica MA. Hyaluronan deposition and correlation with inflammation in a murine ovalbumin model of asthma. Matrix Biol. 2011 Mar;30(2):126-34.
- Cheng G, Swaidani S, Sharma M, Lauer ME, Hascall VC, Aronica MA. Correlation of Hyaluronan Deposition with Infiltration of Eosinophils and Lymphocytes in a Cockroach-Induced Murine Model of Asthma. Glycobiology. 2012 Aug 23.
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