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    • Office of Research Development
    • Clinical & Translational Research
      Participating in Research
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      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Consortium for Pain Genitourinary Malignancies Research Genome Center
      Microbiome & Human Health Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Quantitative Metabolic Research Therapeutics Discovery
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      3D Printing Bioimage Analysis BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Oncology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering >
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      Lerner Research Institute BioRepository Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
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Genome Center

Research

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Key programs/projects

Key programs/projects

  • We are developing advanced experimental genomic technologies, including single-cell multi-omics and spatial proteogenomics.
  • We are building functional genomics portfolios for experimental observations of disease variants and genes, using CRISPRa/CRISPRi and Prime-editing technologies in human iPSC-derived organoids and organ chips.

Genomic and multi-omic studies generate massive amounts of data that require computation. We are developing and perfecting the tools used to analyze this data to improve our capacity to understand what it's telling us about human health and disease.

We are developing generative artificial intelligence models that use multi-omics and linked real-world patient datasets to generate drugs that are predicted to help treat specific diseases. Researchers can use these predictions to make and test these drugs.

Our genomes – the sum total of our DNA – interact with other systems in our body including our proteomes (sum total of our proteins and "human interactome," or how they act), metabolomes and more. We believe the key to understanding human health and disease lies in how these systems intersect with, interact with and influence each other.

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