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Paul Fox Laboratory

❮Cardiovascular & Metabolic Sciences Paul Fox Laboratory
  • Paul Fox Laboratory
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Principal Investigator

Paul Fox Headshot

Paul Fox, PhD

Staff
Robert Canova Endowed Chair in Inflammation Research
Email: [email protected]
Location: Cleveland Clinic Main Campus

Research

The Paul Fox lab studies IFN-gamma signaling, mechanisms of blood vessel formation and ferroxidases in iron metabolism.


Biography

Coming soon.


Education & Professional Highlights

Appointed
1985

Education & Fellowships

Medical Education - Cornell University
Ithaca, NY USA
1983

Undergraduate - Cornell University
Ithaca, NY USA
1969

Fellowship - Cleveland Clinic
Cleveland, OH USA

Research

Research

We have discovered a novel translational control pathway that selectively regulates inflammatory gene expression in myeloid cells, and may be an endogenous regulator of the duration and magnitude of the inflammatory response. IFN-gamma induces expression of certain pro-inflammatory mRNAs, e.g., vascular endothelial growth factor (VEGF)-A and ceruloplasmin, but synthesis of the proteins is limited by translational silencing. IFN-gamma induces assembly of the 4-protein, IFN-Gamma-Activated Inhibitor of Translation (GAIT) complex, that binds a specific RNA element in the 3’untranslated region of target mRNAs, and inhibits translation. We are investigating the signal transduction pathways that lead to activation of the GAIT system, the mechanisms by which two of the proteins escape their parent complexes, and the in vivo function of the pathway. Also, we are taking a ribonomic approach to elucidate the family of targets silenced by this pathway. In other major projects in the laboratory, we investigate the molecular mechanisms that regulate endothelial cell polarization and movement, a critical and initiating event in the formation of new blood vessels and in repair of injured vessels. We also study the role of ferroxidases in cellular and whole-body iron metabolism, and particularly their role in inflammatory diseases and chronic renal failure.

Our Team

Our Team

Publications

Selected Publications

Ray PS, Jia J, Yao P, Majumder M, Hatzoglou M, Fox PL. A stress-responsive RNA switch regulates VEGFA expression. Nature 457:915-919, 2009.

Yao P, Potdar AA, Arif A, Ray PS, Mukhopadhyay R, Willard B, Xu Y, Yan J, Saidel GM, Fox PL. Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 149:88-100, 2012.

Jia J, Arif A, Willard B, Smith J, Stuehr DJ, Hazen SL, Fox PL Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation. Mol Cell 47:656-663, 2012.

Fan Y, Arif A, Gong Y, Jia J, Eswarappa SM, Willard B, Horowitz A, Graham LM, Penn MS, Fox PL. Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol 14:1046-1056, 2012.

Careers

Careers

Training at Lerner Research Institute

Our education and training programs offer hands-on experience at one of the nationʼs top hospitals. Travel, publish in high impact journals and collaborate with investigators to solve real-world biomedical research questions.

Learn More

Research News

Research News

...
New class of disease-causing mutations discovered while studying ultra-rare neurological disorder

Researchers found that a unique form of hypomyelinating leukodystrophy was caused by a genetic mutation that disrupted folding of a single RNA, preventing the binding of important regulatory proteins.



...
Newly identified SARS-CoV-2 infection pathway provides clues to severe cases and obesity link

The SPEAR element (sarbecoviral pan-end activating RNA) and the SPEAR-binding complex are crucial to how SARS-CoV-2 infects host cells to cause COVID-19.



...
Researchers to Study if Non-Coding SARS-CoV-2 Genetic Material Can Offer Insights into New COVID-19 Therapies

Led by Dr. Fox, researchers from Cleveland and Florida will collaborate to investigate if certain regions of SARS-CoV-2 genetic material, called non-coding RNA, can be targeted to treat or prevent COVID-19 infection.



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