Research

Technology Development & Innovation

As a part of a research institute embedded within an international hospital system, we emphasize translational research and are uniquely poised to improve patient care. Our scientists work closely with Cleveland Clinic physicians to transform groundbreaking discoveries made in the laboratory to the bedside.

Intravascular Ultrasound

Cleveland Clinic, working with Volcano (now Philips), helped create the industry-leading intravascular ultrasound (IVUS) product line for coronary plaque characterization. This technology uses advanced, proprietary spectral analysis techniques to classify plaque into four tissue types, with 93-97% accuracy.

Connective Tissue Progenitors

The Regenerative Medicine Laboratory, led by George Muschler, MD, is using advanced imaging and robotic tools to create a novel platform for optimizing tissue-derived, colony-founding connective tissue progenitors. The work will advance the field of cell manufacturing, specifically the expansion of human mesenchymal stromal cells (MSCs), and will greatly improve the quality and reproducibility of MSC manufacturing and use in clinical therapies, drug development and research. Dr. Muschler was awarded $3.3 million from the National Institutes of Health to fund this innovative research.

UroMonitor

The Clinical/Bioanalytical Chemistry program applies the knowledge of chemistry and, in particular, chemical analysis to the study of the origins and diagnoses of diseases. Graduates of this PhD program are employed in many clinical- bioanalytical settings. They become directors of clinical laboratories and research scientists in biomedical and biotechnology fields, in invitro diagnostics, in reference and analytical laboratories, in academic institutions, and in many other settings.

The program is open to college graduates majoring in chemistry, biology, biochemistry, molecular biology and medical technology. Instruction and research in an applied setting of disease diagnosis are integral components of this program.

The UroMonitor is designed to measure bladder pressure and volume for 4-5 days under normal daily activity. Patients can manually input urge, leakage and other sensations into a mobile app for synchronization with UroMonitor measurements. UroMonitor and patient-entered data will be uploaded to a secure database that clinicians can review. Proprietary diagnostic algorithms have been developed to automate data review and assist clinicians with diagnosis.