Christopher Nguyen Lab | Lerner Research Institute

Principal Investigator

Christopher Nguyen, PhD

Associate Staff
Joint Staff, Cardiovascular Medicine
Joint Staff, Imaging Institute
Email: [email protected]
Location: Cleveland Clinic Main Campus

Research

Dr. Nguyen founded and leads the Cardiovascular Innovation Research Center (CIRC). At the intersection of cardiology, biomedical engineering, and radiology, CIRC's single mission is to rapidly translate novel technologies into direct for clinical applications. The Nguyen laboratory's current research focuses on developing next-generation cardiac MRI techniques, evaluation of novel regenerative therapies, patient-specific biomimetic applications (such as digital twins), and integration of machine learning into cardiovascular engineering applications.

Biography

Christopher Nguyen, PhD, serves as the Director of the Cardiovascular Innovation Research Center and MRI Research at the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute, located within the Cleveland Clinic. With a background in biomedical engineering, his primary focus lies in developing and implementing innovative technologies within clinical settings.

Dr. Nguyen obtained his PhD in Biomedical Engineering from the University of California, Los Angeles, following his undergraduate studies in Bioengineering at the University of California, Berkeley. He furthered his training through postdoctoral fellowships in both biomedical imaging at Cedars-Sinai Medical Center, and in cardiology at Massachusetts General Hospital, Harvard Medical School.

Throughout his career, Dr. Nguyen has held academic faculty positions at prestigious institutions, including Cedars-Sinai Medical Center (2017-2018), Massachusetts General Hospital (2017-2022), Harvard Medical School (2017-2023), and Massachusetts Institute of Technology (2021-2023). He joined the staff at the Cleveland Clinic in 2022. Currently, Dr. Nguyen serves as the Principal Investigator (PI) on several National Institutes of Health-funded studies focused on developing innovative cardiovascular techniques and assessing heart failure treatments.

Education & Professional Highlights

University of California, Berkeley, CA	BS	2009	Biomedical Engineering
University of California, Los Angeles, CA	MS	2012	Biomedical Engineering
University of California, Los Angeles, CA	PhD	2015	Biomedical Engineering

PhD Thesis: Clinical Translation of Diffusion Cardiac Magnetic Resonance Imaging: Motion Robust In Vivo Characterization of Myocardial Tissue Microstructure (Doctoral dissertation, University of California, Los Angeles, CA). ProQuest Dissertations Publishing.

Thesis Committee Members: Daniel Ennis PhD, Paul Finn MD, JJ Wang PhD, Peng Hu PhD

Post-Graduate Training

2015-2016 Postdoctoral Research Fellow - MRI Physics & Biomedical Engineering, Cedars-Sinai Medical Center, Los Angeles, CA

2015-2017 Postdoctoral Research Fellow - Cardiology & Cardiovascular Imaging, Massachusetts General Hospital, Boston, MA

Appointments

2022 Associate Staff - Department of Biomedical Engineering, Department of Cardiovascular Medicine, & Imaging Institute

2022 Director - Cleveland Clinic, Heart, Vascular, & Thoracic Institute, Cardiovascular Innovation Research Center

2023 Associate Professor, Medicine - Cleveland Clinic Lerner College of Medicine at CWRU

Prior Appointments

2017-2023 Assistant Investigator/Faculty - Dept. of Cardiology and Radiology, Massachusetts General Hospital, Boston, MA

2017-2018 Research Scientist/Faculty - Dept. of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA

2016-2017 Project Scientist/Faculty - Dept. of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA

Professional Highlights

Dr. Christopher Nguyen, PhD, is a distinguished figure in biomedical engineering, particularly renowned for his pioneering work in cardiovascular innovation. As Director of the Cardiovascular Innovation Research Center (CIRC) at the Cleveland Clinic, he leads groundbreaking research efforts aimed at seamlessly integrating state-of-the-art technologies into clinical practice. Additionally, Dr. Nguyen is highly engaged in scholarly activities, serving as a manuscript reviewer for sixteen journals and three grant-review committees. He also actively participates as a peer reviewer for numerous medical journals, and holds the role of Associate Editor for Frontiers in Cardiovascular Medicine. Furthermore, he is a Fellow of both the American College of Cardiology and the Society of Cardiovascular Magnetic Resonance, contributing his expertise to various councils of the American Heart Association and the National Institutes of Health (NIH).

Dr. Nguyen's diverse research portfolio, spanning from the development of advanced cardiac MRI techniques to the evaluation of regenerative therapies, underscores his unwavering dedication to advancing patient care and understanding heart failure. His remarkable achievements, including being named a "Finalist" for the Novartis Global Scholars Program and receiving the "Best Abstract Award" at the Diabetes Heart Failure Conference, underscore his exceptional leadership and impact on cardiovascular medicine. With over 70 scientific publications in esteemed journals such as Nature Biomedical Engineering, Science Robotics, Circulation, and JACC, coupled with numerous accolades, including the prestigious NIH NIBIB/SCMR Plenary Lecture, Dr. Nguyen has earned international recognition for his significant contributions to cardiovascular imaging and engineering.

Research

Research Support

The lab is grateful for the support received from various organizations over the years. This includes several NIH institutes such as NIAMS, NEI, NICHD, and the NIH-NHLBI Program of Excellence in Glycosciences. Additionally, support has been received from The Marfan Foundation, The Arthritis Foundation, Sabrina's Foundation, Velosano, Yamanouchi USA Foundation, and the Allen Distinguished Investigator Program, facilitated by The Paul G. Allen Frontiers Group and the American Heart Association.

Currently, the lab's research is extramurally supported by grants from NIH-NIAMS, The Arthritis Foundation, and the Ines Mandl Research Foundation. Support is also provided by the Cleveland Clinic Catalyst Caregiver Award.

Our Team

Publications

Selected Publications

View publications for Christopher Nguyen, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Martens P, Ives L, Nguyen CT, Kwon D, Hanna M, Wilson Tang WH. The Impact of Iron Deficiency on Disease Severity and Myocardial Function in Cardiac Amyloidosis. American Journal of Medicine Open. 2024 Jun;11:1000063. https://doi.org/10.1016/j.ajmo.2023.100063.
Sadighi M, Kara D, Mai D, Nguyen K, Chen S, Kwon D, Nguyen C. Cardiac DTI using short-axis PROPELLER: A feasibility study. Magn Reson Med. 2024 Jun;91(6):2546-2558. doi: 10.1002/mrm.30020. PMID: 38376096.
Yang HJ, Nguyen C, Huang LT. Editorial for "Adolescent Reference Values for MR-Derived Biventricular Strain Obtained Using Feature-Tracking and Myocardial Tagging". J Magn Reson Imaging. 2024 May 4. doi: 10.1002/jmri.29432. PMID: 38703126.
Kara D, Koenig K, Lowe M, Nguyen CT, Sakaie K. Facilitating diffusion tensor imaging of the brain during continuous gross head motion with first and second order motion compensating diffusion gradients. Magn Reson Med. 2024 Apr;91(4):1556-1566. doi: 10.1002/mrm.29924. PMID: 38073070.
Kwon DH, Huang S, Turkmani M, Salam D, Al-Dieri D, Ming Wang TK, Kapadia SR, Krishnaswamy A, Gillinov M, Svensson LG, Grimm RA, Tang WHW, Chen D, Nguyen CT, Wang X. Cardiac MRI-Enriched Phenomapping Classification and Differential Treatment Outcomes in Patients With Ischemic Cardiomyopathy. Circ Cardiovasc Imaging. 2024 Apr;17(4):e016006. doi: 10.1161/CIRCIMAGING.123.016006. PMID: 38626097.
Saouaf R, Xie Y, Kim S, Raphael Y, Nguyen C, Luthringer D, Daskivich TJ, Lo E, Tighiouart M, Li D, Kim HL. High-resolution Diffusion-weighted Imaging to Detect Changes in Tumor Size and ADC, and Predict Adverse Biopsy Histology during Prostate Cancer Active Surveillance. Cancer Res Commun. 2024 Mar 27;4(3):938-945. doi: 10.1158/2767-9764.CRC-24-0009. PMID: 38497678.
Anthony CM, Wang TKM, Salam D, Obuchowski N, Turkmani M, Al-Deiri D, Popovic Z, Griffin B, Flamm S, Chen D, Nguyen C, Tang WWH, Kwon D. Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy. JACC Adv. 2024 Feb;3(2):100796. doi: 10.1016/j.jacadv.2023.100796. PMID: 38549681.
Park C, Singh M, Saeed MY, Nguyen CT, Roche ET. Biorobotic hybrid heart as a benchtop cardiac mitral valve simulator. Device. 2024 Jan 19;2(1):100217. doi: 10.1016/j.device.2023.100217. PMID: 38312504.
Nakashima M, Salem D, Tang HW, Nguyen C, Hwang TH, Zhao D, Kim BH, Kwon D, Chen D. Reducing Contextual Bias in Cardiac Magnetic Resonance Imaging Deep Learning Using Contrastive Self-Supervision. Machine Learning for Healthcare Conference. 2023 Dec 22:473-488. PMLR.
Singh, M., Bonnemain, J., Ozturk, C, Ayers B, Saeed MY, Quevedo-Moreno D, Rowlett M, Park C, Fan Y, Nguyen CT, Roche ET. Robotic right ventricle is a biohybrid platform that simulates right ventricular function in (patho)physiological conditions and intervention. Nat Cardiovasc Res 2, 2023 Dec 8:1310–1326. https://doi.org/10.1038/s44161-023-00387-8
Moulin K, Stoeck CT, Axel L, Broncano J, Croisille P, Dall'Armellina E, Ennis DB, Ferreira PF, Gotschy A, Miro S, Schneider JE, Scott AD, Sosnovik DE, Teh I, Tous C, Tunnicliffe EM, Viallon M, Nguyen C. In Vivo Cardiac Diffusion Imaging Without Motion-Compensation Leads to Unreasonably High Diffusivity. J Magn Reson Imaging. 2023 Dec;58(6):1990-1991. doi: 10.1002/jmri.28703. PMID: 37000010.
Klein V, Davids M, Vendramini L, Ferris NG, Schad LR, Sosnovik DE, Nguyen CT, Wald LL, Guérin B. Prediction of experimental cardiac magnetostimulation thresholds using pig-specific body models. Magn Reson Med. 2023 Oct;90(4):1594-1609. doi: 10.1002/mrm.29717. PMID: 37288580.
Coll-Font J, Nguyen C. Editorial for "IOP Injection, A Novel Superparamagnetic Iron Oxide Particle MRI Contrast Agent for the Detection of Hepatocellular Carcinoma: A Phase II Clinical Trial". J Magn Reson Imaging. 2023 Oct;58(4):1189-1190. doi: 10.1002/jmri.28657. Epub 2023 Feb 23. PMID: 36820512.
Joy G, Kelly CI, Webber M, Pierce I, Teh I, McGrath L, Velazquez P, Hughes RK, Kotwal H, Das A, Chan F, Bakalakos A, Lorenzini M, Savvatis K, Mohiddin SA, Macfarlane PW, Orini M, Manisty C, Kellman P, Davies RH, Lambiase PD, Nguyen C, Schneider JE, Tome M, Captur G, Dall'Armellina E, Moon JC, Lopes LR. Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy. Circulation. 2023 Sep 5;148(10):808-818. doi: 10.1161/CIRCULATIONAHA.123.063835. PMID: 37463608.
Shusharina N, Nguyen C. Consistency of muscle fibers directionality in human thigh derived from diffusion-weighted MRI. Phys Med Biol. 2023 Sep 1;68(17):175045. doi: 10.1088/1361-6560/acf10c. PMID: 37586375.
Yurista SR, Eder RA, Feeley M, Kodur N, Wilson Tang WH, Nguyen CT. A Closer Look at ACC/AHA and ESC Guidelines for Managing Obesity and Overweight in Adults. JACC Advances. 2023 Sep;2(7):100570. https://doi.org/10.1016/j.jacadv.2023.100570
Yurista SR, Eder RA, Welsh A, Jiang W, Chen S, Foster AN, Mauskapf A, Tang WHW, Hucker WJ, Coll-Font J, Rosenzweig A, Nguyen CT. Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction. Metabolism. 2023 Aug;145:155608. doi: 10.1016/j.metabol.2023.155608. PMID: 37268056.
Rosalia L, Wang SX, Ozturk C, Huang W, Bonnemain J, Beatty R, Duffy GP, Nguyen CT, Roche ET. Soft robotic platform for controlled, progressive and reversible aortic constriction in a small animal model. Res Sq [Preprint]. 2023 Jul 19:rs.3.rs-3100659. doi: 10.21203/rs.3.rs-3100659/v1. PMID: 37503291.
Kodur N, Yurista S, Province V, Rueth E, Nguyen C, Tang WHW. Ketogenic Diet in Heart Failure: Fact or Fiction? JACC Heart Fail. 2023 Jul;11(7):838-844. doi: 10.1016/j.jchf.2023.05.009. PMID: 37407158.
Kim D, Coll-Font J, Lobos RA, Stäb D, Pang J, Foster A, Garrett T, Bi X, Speier P, Haldar JP, Nguyen C. Single breath-hold CINE imaging with combined simultaneous multislice and region-optimized virtual coils. Magn Reson Med. 2023 Jul;90(1):222-230. doi: 10.1002/mrm.29620. PMID: 36864561.
Yurista SR, Chen S, Eder RA, Garrett T, Butsch WS, Aminian A, Tang WHW, Farrar CT, Gee D, Abel ED, Das S, Nguyen CT. Mapping the Unseen: In Vivo CEST-MRI of Creatine Reveals Improved Cardiac Energetics in Subjects with Obesity Following Bariatric Surgery. Obes Surg. 2023 Jun;33(6):1944-1948. doi: 10.1007/s11695-023-06589-0. PMID: 37058265.
Weigand-Whittier J, Sedykh M, Herz K, Coll-Font J, Foster AN, Gerstner ER, Nguyen C, Zaiss M, Farrar CT, Perlman O. Accelerated and quantitative three-dimensional molecular MRI using a generative adversarial network. Magn Reson Med. 2023 May;89(5):1901-1914. doi: 10.1002/mrm.29574. PMID: 36585915.
Bonner BP, Yurista SR, Coll-Font J, Chen S, Eder RA, Foster AN, Nguyen KD, Caravan P, Gale EM, Nguyen C. Contrast-Enhanced Cardiac Magnetic Resonance Imaging With a Manganese-Based Alternative to Gadolinium for Tissue Characterization of Acute Myocardial Infarction. J Am Heart Assoc. 2023 Apr 18;12(8):e026923. doi: 10.1161/JAHA.122.026923. PMID: 37042259.
Qiu J, Huang P, Nakashima M, Lee J, Zhu, J, Tang W, Chen P, Nguyen C, Kim BH, Kwon D, Weber D. Multimodal Representation Learning of Cardiovascular Magnetic Resonance Imaging. arXiv preprint arXiv: 2023 Apr 16:2304.07675.
Nguyen KD, Bonner BP, Foster AN, Sadighi M, Nguyen CT. Asynchronous magnetic resonance elastography: Shear wave speed reconstruction using noise correlation of incoherent waves. Magn Reson Med. 2023 Mar;89(3):990-1001. doi: 10.1002/mrm.29502. PMID: 36300861.
Rosalia L, Ozturk C, Goswami D, Bonnemain J, Wang SX, Bonner B, Weaver JC, Puri R, Kapadia S, Nguyen CT, Roche ET. Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling. Sci Robot. 2023 Feb 22;8(75):eade2184. doi: 10.1126/scirobotics.ade2184. PMID: 36812335. **Featured on Cover of Jan. 2023 Issue & on CNN (4/1/22).
Lo Presti S, Eck BL, Reyaldeen R, Nguyen C, Tang WHW, Flamm SD, Seiberlich N, Lima da Cruz G, Prieto C, Kwon DH. Fingerprinting MINOCA: Unraveling Clues With Quantitative CMR. JACC Case Rep. 2023 Feb 1;7:101722. doi: 10.1016/j.jaccas.2022.101722. PMID: 36776793.
Djenoune L, Mahamdeh M, Truong TV, Nguyen CT, Fraser SE, Brueckner M, Howard J, Yuan S. Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry. Science. 2023 Jan 6;379(6627):71-78. doi: 10.1126/science.abq7317. PMID: 36603098.
Akerberg AA, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu WT, Burns CE, Burns CG. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 Dec 2;131(12):980-1000. doi: 10.1161/CIRCRESAHA.122.321728. PMID: 36367103. **Featured on Cover of Nov 2022 Issue.
Snel GJH, Slart RHJA, Velthuis BK, van den Boomen M, Nguyen CT, Sosnovik DE, van Deursen VM, Dierckx RAJO, Borra RJH, Prakken NHJ. Interpretation of pre-morbid cardiac 3T MRI findings in overweight and hypertensive young adults. PLoS One. 2022 Dec 1;17(12):e0278308. doi: 10.1371/journal.pone.0278308. PMID: 36454872.
Ozturk C, Schmid Daners M, Zhao X, Roche ET, Nguyen CT. Editorial: Cardiovascular engineering. Front Cardiovasc Med. 2022 Nov 21;9:1089794. doi: 10.3389/fcvm.2022.1089794. PMID: 36479566.
Kim JJH, Parajuli S, Sinha A, Mahamdeh M, van den Boomen M, Coll-Font J, Chen LS, Fan Y, Eder RA, Phipps K, Yuan S, Nguyen C. Pocket CLARITY enables distortion-mitigated cardiac microstructural tissue characterization of large-scale specimens. Front Cardiovasc Med. 2022 Nov 14;9:1037500. doi: 10.3389/fcvm.2022.1037500. PMID: 36451924.
Klein V, Coll-Font J, Vendramini L, Straney D, Davids M, Ferris NG, Schad LR, Sosnovik DE, Nguyen CT, Wald LL, Guérin B. Measurement of magnetostimulation thresholds in the porcine heart. Magn Reson Med. 2022 Nov;88(5):2242-2258. doi: 10.1002/mrm.29382. PMID: 35906903.
Huang M, Akerberg AA, Zhang X, Yoon H, Joshi S, Hallinan C, Nguyen C, Pu WT, Haigis MC, Burns CG, Burns CE. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun. 2022 Oct 5;13(1):5877. doi: 10.1038/s41467-022-32982-x. PMID: 36198703.
Sclocco R, Fisher H, Staley R, Han K, Mendez A, Bolender A, Coll-Font J, Kettner NW, Nguyen C, Kuo B, Napadow V. Cine gastric MRI reveals altered Gut-Brain Axis in Functional Dyspepsia: gastric motility is linked with brainstem-cortical fMRI connectivity. Neurogastroenterol Motil. 2022 Oct;34(10):e14396. doi: 10.1111/nmo.14396. PMID: 35560690.
Rosalia L, Ozturk C, Coll-Font J, Fan Y, Nagata Y, Singh M, Goswami D, Mauskapf A, Chen S, Eder RA, Goffer EM, Kim JH, Yurista S, Bonner BP, Foster AN, Levine RA, Edelman ER, Panagia M, Guerrero JL, Roche ET, Nguyen CT. A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis. Nat Biomed Eng. 2022 Oct;6(10):1134-1147. doi: 10.1038/s41551-022-00937-8. PMID: 36163494. **Featured on Cover of Oct. 2022 Issue.
Martens P, Nguyen C, Tang WHW. Is epicardial adipose tissue a key pathophysiologic target in heart failure with preserved ejection? J Mol Cell Cardiol. 2022 Oct;171:69-70. doi: 10.1016/j.yjmcc.2022.07.003. PMID: 35868216.
Yurista SR, Eder RA, Kwon DH, Farrar CT, Yen YF, Tang WHW, Nguyen CT. Magnetic resonance imaging of cardiac metabolism in heart failure: how far have we come? Eur Heart J Cardiovasc Imaging. 2022 Sep 10;23(10):1277-1289. doi: 10.1093/ehjci/jeac121. PMID: 35788836.
Yurista SR, Chen S, Welsh A, Tang WHW, Nguyen CT. Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time? Curr Heart Fail Rep. 2022 Aug;19(4):180-190. doi: 10.1007/s11897-022-00554-1. PMID: 35567658.
Shusharina N, Liu X, Coll-Font J, Foster A, El Fakhri G, Woo J, Bortfeld T, Nguyen C. Feasibility study of clinical target volume definition for soft-tissue sarcoma using muscle fiber orientations derived from diffusion tensor imaging. Phys Med Biol. 2022 Jul 22;67(15):10.1088/1361-6560/ac8045. doi: 10.1088/1361-6560/ac8045. PMID: 35817048.
Eder RA, van den Boomen M, Yurista SR, Rodriguez-Aviles YG, Islam MR, Chen YI, Trager L, Coll-Font J, Cheng L, Li H, Rosenzweig A, Wrann CD, Nguyen CT. Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity. Commun Biol. 2022 Jul 4;5(1):656. doi: 10.1038/s42003-022-03635-y. Erratum in: Commun Biol. 2022 Jul 13;5(1):696. PMID: 35787681.
Eder RA, van den Boomen M, Yurista SR, Rodriguez-Aviles YG, Islam MR, Chen YI, Trager L, Coll-Font J, Cheng L, Li H, Rosenzweig A, Wrann CD, Nguyen CT. Author Correction: Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity. Commun Biol. 2022 Jul 13;5(1):696. doi: 10.1038/s42003-022-03671-8. Erratum for: Commun Biol. 2022 Jul 4;5(1):656. PMID: 35831490.
Teh I, Romero R WA, Boyle J, Coll-Font J, Dall'Armellina E, Ennis DB, Ferreira PF, Kalra P, Kolipaka A, Kozerke S, Lohr D, Mongeon FP, Moulin K, Nguyen C, Nielles-Vallespin S, Raterman B, Schreiber LM, Scott AD, Sosnovik DE, Stoeck CT, Tous C, Tunnicliffe EM, Weng AM, Croisille P, Viallon M, Schneider JE. Validation of cardiac diffusion tensor imaging sequences: A multicentre test-retest phantom study. NMR Biomed. 2022 Jun;35(6):e4685. doi: 10.1002/nbm.4685. PMID: 34967060.
Illi J, Bernhard B, Nguyen C, Pilgrim T, Praz F, Gloeckler M, Windecker S, Haeberlin A, Gräni C. Translating Imaging Into 3D Printed Cardiovascular Phantoms: A Systematic Review of Applications, Technologies, and Validation. JACC Basic Transl Sci. 2022 Apr 6;7(10):1050-1062. doi: 10.1016/j.jacbts.2022.01.002. PMID: 36337920.
Das A, Kelly C, Teh I, Nguyen C, Brown LAE, Chowdhary A, Jex N, Thirunavukarasu S, Sharrack N, Gorecka M, Swoboda PP, Greenwood JP, Kellman P, Moon JC, Davies RH, Lopes LR, Joy G, Plein S, Schneider JE, Dall'Armellina E. Phenotyping hypertrophic cardiomyopathy using cardiac diffusion magnetic resonance imaging: the relationship between microvascular dysfunction and microstructural changes. Eur Heart J Cardiovasc Imaging. 2022 Feb 22;23(3):352-362. doi: 10.1093/ehjci/jeab210. PMID: 34694365.
Snel GJH, van den Boomen M, Hurtado-Ortiz K, Slart RHJA, van Deursen VM, Nguyen CT, Sosnovik DE, Dierckx RAJO, Velthuis BK, Borra RJH, Prakken NHJ. Cardiac Alterations on 3T MRI in Young Adults With Sedentary Lifestyle-Related Risk Factors. Front Cardiovasc Med. 2022 Feb 22;9:840790. doi: 10.3389/fcvm.2022.840790. PMID: 35274012.
Zhong Y, Mahoney RC, Khatun Z, Chen HH, Nguyen CT, Caravan P, Roberts JD Jr. Lysyl oxidase regulation and protein aldehydes in the injured newborn lung. Am J Physiol Lung Cell Mol Physiol. 2022 Feb 1;322(2):L204-L223. doi: 10.1152/ajplung.00158.2021. PMID: 34878944.
Malhotra R, Nicholson CJ, Wang D, Bhambhani V, Paniagua S, Slocum C, Sigurslid HH, Lino Cardenas CL, Li R, Boerboom SL, Chen YC, Hwang SJ, Yao C, Ichinose F, Bloch DB, Lindsay ME, Lewis GD, Aragam JR, Hoffmann U, Mitchell GF, Hamburg NM, Vasan RS, Benjamin EJ, Larson MG, Zapol WM, Cheng S, Roh JD, O'Donnell CJ, Nguyen C, Levy D, Ho JE. Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction. Arterioscler Thromb Vasc Biol. 2022 Feb;42(2):e61-e73. doi: 10.1161/ATVBAHA.121.316664. PMID: 34809448. **Editor's Pick for Feb. 2022.
Coll-Font J, Chen S, Eder R, Fang Y, Han QJ, van den Boomen M, Sosnovik DE, Mekkaoui C, Nguyen CT. Manifold-based respiratory phase estimation enables motion and distortion correction of free-breathing cardiac diffusion tensor MRI. Magn Reson Med. 2022 Jan;87(1):474-487. doi: 10.1002/mrm.28972. PMID: 34390021. **Top-Selected "Journal Club Talk" for ISMRM Motion Study Group 2021.
Ho JE, Nguyen C, Lewis GD. Unmasking Nonpreserved Heart Structure, Function, and Energetics in Heart Failure With Preserved Ejection Fraction With Magnetic Resonance Imaging Coupled With Exercise. Circulation. 2021 Nov 23;144(21):1679-1682. doi: 10.1161/CIRCULATIONAHA.121.056974. PMID: 34743526.
Dang A, Khaled Soufi M, Nguyen C, Orndorff J, Baliss M, Berbarie RF, Khalife WI. The Burden of Hospitalizations for Vaccine-Preventable Infections in Heart Transplant Recipients. Am J Cardiol. 2021 Oct 15;157:148-150. doi: 10.1016/j.amjcard.2021.07.010. PMID: 34373079.
Yurista SR, Rosenzweig A, Nguyen CT. Ketone Bodies: Universal Cardiac Response to Stress? J Am Coll Cardiol. 2021 Oct 5;78(14):1433-1436. doi: 10.1016/j.jacc.2021.08.002. PMID: 34593125.
Yurista SR, Nguyen CT, Rosenzweig A, de Boer RA, Westenbrink BD. Ketone bodies for the failing heart: fuels that can fix the engine? Trends Endocrinol Metab. 2021 Oct;32(10):814-826. doi: 10.1016/j.tem.2021.07.006. PMID: 34456121.
Snel GJH, Poort S, Velthuis BK, van Deursen VM, Nguyen CT, Sosnovik D, Dierckx RAJO, Slart RHJA, Borra RJH, Prakken NHJ. Balancing Speed and Accuracy in Cardiac Magnetic Resonance Function Post-Processing: Comparing 2 Levels of Automation in 3 Vendors to Manual Assessment. Diagnostics (Basel). 2021 Sep 24;11(10):1758. doi: 10.3390/diagnostics11101758. PMID: 34679457.
Morales MA, van den Boomen M, Nguyen C, Kalpathy-Cramer J, Rosen BR, Stultz CM, Izquierdo-Garcia D, Catana C. DeepStrain: A Deep Learning Workflow for the Automated Characterization of Cardiac Mechanics. Front Cardiovasc Med. 2021 Sep 3;8:730316. doi: 10.3389/fcvm.2021.730316. PMID: 34540923.
Fan Y, Coll-Font J, van den Boomen M, Kim JH, Chen S, Eder RA, Roche ET, Nguyen CT. Characterization of Exercise-Induced Myocardium Growth Using Finite Element Modeling and Bayesian Optimization. Front Physiol. 2021 Aug 9;12:694940. doi: 10.3389/fphys.2021.694940. PMID: 34434115.
Sclocco R, Nguyen C, Staley R, Fisher H, Mendez A, Velez C, Kettner NW, Kuo B, Napadow V. Non-uniform gastric wall kinematics revealed by 4D Cine magnetic resonance imaging in humans. Neurogastroenterol Motil. 2021 Aug;33(8):e14146. doi: 10.1111/nmo.14146. PMID: 33797166.
Phipps K, van de Boomen M, Eder R, Michelhaugh SA, Spahillari A, Kim J, Parajuli S, Reese TG, Mekkaoui C, Das S, Gee D, Shah R, Sosnovik DE, Nguyen C. Accelerated in Vivo Cardiac Diffusion-Tensor MRI Using Residual Deep Learning-based Denoising in Participants with Obesity. Radiol Cardiothorac Imaging. 2021 Jun 24;3(3):e200580. doi: 10.1148/ryct.2021200580. PMID: 34250491. **Cover of Journal for Jun 2021
Nguyen CT, Christodoulou AG, Coll-Font J, Ma S, Xie Y, Reese TG, Mekkaoui C, Lewis GD, Bi X, Sosnovik DE, Li D. Free-breathing diffusion tensor MRI of the whole left ventricle using second-order motion compensation and multitasking respiratory motion correction. Magn Reson Med. 2021 May;85(5):2634-2648. doi: 10.1002/mrm.28611. PMID: 33252140.
Sclocco R, Nguyen C, Staley R, Fisher H, Mendez A, Han K, Kuo B, Napadow V. Reported abdominal pain is associated with gastric motility in functional dyspepsia pateints. The Journal of Pain. 2021 May;22(5):601. https://doi.org/10.1016/j.jpain.2021.03.095.
Kim D, Wisnowski JL, Nguyen CT, Haldar JP. Multidimensional correlation spectroscopic imaging of exponential decays: From theoretical principles to in vivo human applications. NMR Biomed. 2020 Dec;33(12):e4244. doi: 10.1002/nbm.4244. PMID: 31909534.
Snel GJH, Hernandez LM, Slart RHJA, Nguyen CT, Sosnovik DE, van Deursen VM, Dierckx RAJO, Velthuis BK, Borra RJH, Prakken NHJ. Validation of thoracic aortic dimensions on ECG-triggered SSFP as alternative to contrast-enhanced MRA. Eur Radiol. 2020 Nov;30(11):5794-5804. doi: 10.1007/s00330-020-06963-x. PMID: 32506262.
Islam MR, Luo R, Valaris S, Haley EB, Takase H, Chen YI, Dickerson BC, Schon K, Arai K, Nguyen CT, Wrann CD. Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice. Brain Plast. 2020 Oct 1;5(2):147-159. doi: 10.3233/BPL-190090. PMID: 33282678.
Kashkoush AI, Nguyen C, Balzer J, Habeych M, Crammond DJ, Thirumala PD. Diagnostic accuracy of somatosensory evoked potentials during intracranial aneurysm clipping for perioperative stroke. J Clin Monit Comput. 2020 Aug;34(4):811-819. doi: 10.1007/s10877-019-00369-x. PMID: 31399827.
Ma S, Nguyen CT, Han F, Wang N, Deng Z, Binesh N, Moser FG, Christodoulou AG, Li D. Three-dimensional simultaneous brain T1 , T2 , and ADC mapping with MR Multitasking. Magn Reson Med. 2020 Jul;84(1):72-88. doi: 10.1002/mrm.28092. PMID: 31765496.
Snel GJH, van den Boomen M, Hernandez LM, Nguyen CT, Sosnovik DE, Velthuis BK, Slart RHJA, Borra RJH, Prakken NHJ. Correction to: Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis. J Cardiovasc Magn Reson. 2020 Jun 15;22(1):47. doi: 10.1186/s12968-020-00646-8. Erratum for: J Cardiovasc Magn Reson. 2020 May 11;22(1):34. PMID: 32539820.
Snel GJH, van den Boomen M, Hernandez LM, Nguyen CT, Sosnovik DE, Velthuis BK, Slart RHJA, Borra RJH, Prakken NHJ. Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis. J Cardiovasc Magn Reson. 2020 May 11;22(1):34. doi: 10.1186/s12968-020-00627-x. Erratum in: J Cardiovasc Magn Reson. 2020 Jun 15;22(1):47. PMID: 32393281.
van den Boomen M, Manhard MK, Snel GJH, Han S, Emblem KE, Slart RHJA, Sosnovik DE, Catana C, Rosen BR, Prakken NHJ, Nguyen CT, Borra RJH, Setsompop K. Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging. Radiology. 2020 Mar;294(3):538-545. doi: 10.1148/radiol.2020191845. PMID: 31961241.
Park C, Fan Y, Hager G, Yuk H, Singh M, Rojas A, Hameed A, Saeed M, Vasilyev NV, Steele TWJ, Zhao X, Nguyen CT, Roche ET. An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging. Sci Robot. 2020 Jan 29;5(38):eaay9106. doi: 10.1126/scirobotics.aay9106. PMID: 33022595. **Article broadcasted by multiple media/news outlets
Akerberg AA, Burns CE, Burns CG, Nguyen C. Deep learning enables automated volumetric assessments of cardiac function in zebrafish. Dis Model Mech. 2019 Oct 25;12(10):dmm040188. doi: 10.1242/dmm.040188. PMID: 31548281. **Cover of Oct. 2019 Issue
Shaw JL, Yang Q, Zhou Z, Deng Z, Nguyen C, Li D, Christodoulou AG. Free-breathing, non-ECG, continuous myocardial T1 mapping with cardiovascular magnetic resonance multitasking. Magn Reson Med. 2019 Apr;81(4):2450-2463. doi: 10.1002/mrm.27574. PMID: 30450749.
Lee SE, Nguyen C, Xie Y, Deng Z, Zhou Z, Li D, Chang HJ. Recent Advances in Cardiac Magnetic Resonance Imaging. Korean Circ J. 2019 Feb;49(2):146-159. doi: 10.4070/kcj.2018.0246. PMID: 30468040.
Ma S, Nguyen CT, Christodoulou AG, Luthringer D, Kobashigawa J, Lee SE, Chang HJ, Li D. Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints. IEEE Trans Biomed Eng. 2018 Oct;65(10):2219-2230. doi: 10.1109/TBME.2017.2787111. PMID: 29989936.
Buckberg GD, Nanda NC, Nguyen C, Kocica MJ. What Is the Heart? Anatomy, Function, Pathophysiology, and Misconceptions. J Cardiovasc Dev Dis. 2018 Jun 4;5(2):33. doi: 10.3390/jcdd5020033. PMID: 29867011.
Lee SE, Nguyen C, Yoon J, Chang HJ, Kim S, Kim CH, Li D. Three-dimensional Cardiomyocytes Structure Revealed By Diffusion Tensor Imaging and Its Validation Using a Tissue-Clearing Technique. Sci Rep. 2018 Apr 27;8(1):6640. doi: 10.1038/s41598-018-24622-6. PMID: 29703900.
Liu W, Xie Y, Wang C, Du Y, Nguyen C, Wang Z, Fan Z, Dong L, Liu Y, Bi X, An J, Gu C, Yu W, Li D. Atherosclerosis T1-weighted characterization (CATCH): evaluation of the accuracy for identifying intraplaque hemorrhage with histological validation in carotid and coronary artery specimens. J Cardiovasc Magn Reson. 2018 Apr 26;20(1):27. doi: 10.1186/s12968-018-0447-x. PMID: 29695254.
Christodoulou AG, Shaw JL, Nguyen C, Yang Q, Xie Y, Wang N, Li D. Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging. Nat Biomed Eng. 2018 Apr;2(4):215-226. doi: 10.1038/s41551-018-0217-y. PMID: 30237910.
Nguyen CT, Dawkins J, Bi X, Marbán E, Li D. Diffusion Tensor Cardiac Magnetic Resonance Reveals Exosomes From Cardiosphere-Derived Cells Preserve Myocardial Fiber Architecture After Myocardial Infarction. JACC Basic Transl Sci. 2018 Feb;3(1):97-109. doi: 10.1016/j.jacbts.2017.09.005. PMID: 29600288.

Patents

US Patent	Patent Title	Issue Date	First-Named Inventor
US20180306882A1	Low-rank tensor imaging for multidimensional cardiovascular mri	10/08/2019	Debiao Li
US10649056B2	Free-breathing 3D body diffusion imaging using motion-compensated diffusion preparation and motion robust readout		Xiaoming Bi
WO2021226186A1	An organosynthetic dynamic heart model	10/24/2023	Clara Park
US20210356544A1	Low-rank tensor imaging for quantitative mri	11/11/2021	Debiao Li

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Heart Month 2025: Questions researchers are asking to improve heart health

Recent cardiovascular research at Cleveland Clinic examined topics such as the gut microbiome connection to the heart, COVID-19’s impact on cardiac event risk and improving cardiac imaging.

What is diffusion MRI: how advanced cardiac imaging can benefit care, research

Dr. Christopher Nguyen discusses current challenges in heart screening and imaging, and how he’s overcoming them by advancing cardiac MRI.

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