Selected Publications

  1. Yan, R., Bienkowski, M.J., Shuck, M.E., Miao, H., Tory, M.C., Pauley, A.M., Brashier, J.R., Stratman, N.C., Mathews, W.R., Buhl, A.E., Carter, D.B., Tomasselli, A.G., Parodi, L.A., Heinrikson, R.L., and Gurney, M.E. (1999). Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402, 533-537.

  2. Yan, R., Han, P., Miao, H., Greengard, P., and Xu, H. (2001a). The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. J. Biol. Chem. 276, 36788-36796.

  3. Yan, R., Munzner, J.B., Shuck, M.E., and Bienkowski, M.J. (2001b). BACE2 functions as an alternative alpha-secretase in cells. J. Biol. Chem. 276, 34019-34027.

  4. Li, J., Pauley, A.M., Myers, R.L., Shuang, R., Brashler, J.R., Yan, R., Buhl, A.E., Ruble, C., and Gurney, M.E. (2002). SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. J. Neurochem. 82, 1540-1548.

  5. Yang, L.B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.L., Beach, T., Sue, L., Wong, P., Price, D., Li, R., and Shen, Y. (2003). Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat. Med. 9, 3-4.

  6. Tomasselli, A.G., Qahwash, I., Emmons, T.L., Lu, Y., Leone, J.W., Lull, J.M., Fok, K.F., Bannow, C.A., Smith, C.W., Bienkowski, M.J., Heinrikson, R.L., and Yan, R. (2003). Employing a superior BACE1 cleavage sequence to probe cellular APP processing. J. Neurochem. 84, 1006-1017.

  7. Qahwash, I., Weiland, K.L., Lu, Y., Sarver, R.W., Kletzien, R.F., and Yan, R. (2003). Identification of a mutant amyloid peptide that predominantly forms neurotoxic protofibrillar aggregates. J. Biol. Chem. 278, 23187-23195.

  8. He, W., Lu, Y., Qahwash, I., Hu, X.Y., Chang, A., and Yan, R. (2004). Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. Nat. Med. 10, 959-965.

  9. Li, R., Lindholm, K., Yang, L.B., Yue, X., Citron, M., Yan, R., Beach, T., Sue, L., Sabbagh, M., Cai, H., Wong, P., Price, D., and Shen, Y. (2004). Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc. Natl. Acad. Sci. U. S. A. 101, 3632-3637.

  10. Qahwash, I., He, W., Tomasselli, A., Kletzien, R.F., and Yan, R. (2004). Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. J. Biol. Chem. 279, 39010-39016.

  11. He, W., Hu, X., Shi, Q., Zhou, X., Lu, Y., Fisher, C., and Yan, R. (2006). Mapping of Interaction Domains Mediating Binding between BACE1 and RTN/Nogo Proteins. J. Mol. Biol. 363, 625-634.

  12. Hu, X., Hicks, C.W., He, W., Wong, P., Macklin, W.B., Trapp, B.D., and Yan, R. (2006). Bace1 modulates myelination in the central and peripheral nervous system. Nat. Neurosci. 9, 1520-1525.

  13. Wojcik, S., Engel, W.K., Yan, R., McFerrin, J., and Askanas, V. (2007). NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in AbetaPP-overexpressing cultured human muscle fibers. Acta Neuropathol. (Berl) 114, 517-526.

  14. He, W., Shi, Q., Hu, X., and Yan, R. (2007). The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1. J. Biol. Chem. 282, 29144-29151.

  15. Hu, X., Shi, Q., Zhou, X., He, W., Yi, H., Yin, X., Gearing, M., Levey, A., and Yan, R. (2007). Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. EMBO. J. 26, 2755-2767.

  16. Carter, D.B., Dunn, E., Pauley, A.M., McKinley, D.D., Fleck, T.J., Ellerbrook, B.R., Stratman, N.C., Zhou, X., Himes, C.S., Nye, J.S., Tomasselli, A., and Yan, R. (2008). Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1. Mol. Neurodegener. 3, 6.

  17. Breij, E.C., Brink, B.P., Veerhuis, R., van den Berg, C., Vloet, R., Yan, R., Dijkstra, C.D., van der Valk, P., and Bo, L. (2008) Homogeneity of active demyelinating lesions in established multiple sclerosis. Ann. Neurol. 63:16-25.

  18. Hu, X., He, W., Diaconu, C., Tang, X., Kidd, G.J., Macklin, W.B., Trapp, B.D., and Yan, R. (2008) Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB. J. 22:2970-2980.

  19. Shi, Q., Hu, X., Prior, M., and Yan, R. (2009a) The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function. J Neurosci. 29:5108-5115.

  20. Shi, Q., Prior, M., He, W., Tang, X., Hu, X., and Yan, R. (2009b) Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites. J. Neurosci. 29:9163-9173.

  21. Vassar, R., Kovacs, D.M., Yan, R., and Wong, P.C. (2009) The {beta}-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential. J. Neurosci. 29:12787-12794.

  22. Zhang, Y., Xiong, M., Yan, R., and Sun, F.Y. (2009). Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats. J. Cereb. Blood Flow Metab. In Press.