Recent Publications:

Chen, B.-R. and Runge, K.W. Unbiased Genetic Approaches to Yeast Aging: New Connections and New Opportunities. In: “Aging Research in Yeast”. Michal Jazwinski, Peter Laun and Michael Breitenbach, eds.; Published by Springer. (in press)

Abdallah, P., Luciano, P., Runge, K.W., Lisby, M., Géli, V., Gilson, E., and Teixeira, M.T. (2009) A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol. 11, 988-993. Erratum in: Nat Cell Biol. 2010 May;12(5):520.

Chen, B.R., and Runge, K.W. (2009) A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity. Exp Gerontol. 44, 493-502. PMCID: PMC2795633.

Hector, R.E., Shtofman, R.L., Ray, A., Chen, B.R., Nyun, T., Berkner, K.L. and Runge, K.W. (2007) Tel1p preferentially associates with short telomeres to stimulate their elongation. Mol Cell. 27, 851-858.

Runge KW. Telomeres and aging in the yeast model system. In: "Handbook of models for human aging". Conn, P.M., ed.; Amsterdam; Boston: Elsevier Academic Press; 2006. Ch. 17. pp. 191-205.

Ray*, A., Hector*, R.E., Roy, N., Song, J.-H., Berkner, K.L. and Runge, K.W. (2003) Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened life span. Nat Genet. 33, 522-526 *co-first authors.

Ray, A., and Runge, K.W. (2001) Yeast Telomerase Appears to Frequently Copy the Entire Template In Vivo. Nucl Acids Res. 29, 2382-2394.

Roy, N., and Runge, K.W. (2000) Two paralogous genes antagonistically control yeast life span. Curr Biol. 10, 111-114.

Ray, A., and Runge, K.W. (1999b) Varying the number of telomere bound proteins does not alter telomere length in tel1-delta cells. Proc Natl Acad Sci U S A. 96, 15044-15049.

Kota, R., and Runge, K.W. (1999) Tel2p, a regulator of yeast telomere length in vivo, binds to single-stranded telomeric DNA in vitro. Chromosoma. 108, 278-290.

Roy, N., and Runge, K.W. (1999) The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromere plasmids. Chromosoma. 108, 146-161.

Ray, A., and Runge, K.W. (1999a) The yeast telomere length counting machinery is critically sensitive to sequences at the telomere/non-telomere junction. Mol Cell Biol. 19, 31-45.

Ray, A., and Runge, K.W. (1998) The C-terminus of the major yeast telomere binding protein Rap1p enhances telomere formation. Mol Cell Biol. 18, 1284-1295.

Kota, R.S., and Runge, K.W. (1998) The telomere length regulator TEL2 encodes a protein that binds to telomeric DNA. Nucl Acids Res. 26, 1528-1535.