Selected Key References

  1. Ithychanda, S., Das, M., Ma, Y.Q., Ding, K., Wang, X., Gupta, S., Wu, C., Plow, E.F., and Qin, J. Migflilin - A molecular switch for regulation of integrin activation. J. Biol. Chem., 284:4713-4722, 2009. PMID:19074766
  2. Yang, Y., Wang, X., Hawkins, C.A., Chen, K., Vaynberg, J., Mao, X., Tu, Y., Zuo, X., Wang, Y.X., Wu, C., Tjandra, N., and Qin, J. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J. Biol. Chem., 284(9):5836-5844, 2009. PMID: 19117955
  3. Wang, J.B., Zuo, X.B., Yu, P., Byeon, I-J, Jung, J.W., WAng, X.X., Dyba, M., Siefert, S., Schwieters, C.D., Qin, J., Gronenborn, A.M., and Wang, Y.X. Determination of multicomponent protein structures in solution using global orientation and shape restraints. J. Amer. Chem. Soc., 131:10507-10515, 2009. PMID: 19722627
  4. Plow, E.F., Qin, J., and Byzova T.V. Kindling the flame of integrin activation and function with kindlins. Curr. Opin. Hematol., 16:323-328, 2009. PMID: 19553810
  5. Zhao, J., Zhang, Y., Ithychanda, S., Tu, Y., Chen, K., Qin, J., and Wu, C. Migfilin activates Src and links cell-matrix adhesion to cell survival. J. Biol. Chem., 284:34308-34320, 2009. PMID: 19833732
  6. Ithychanda, S.S., Hsu, D., Li, H., Yan, L., Liu, D., Das, M., Plow, E.F., Qin, J. Identification and characterization of multiple similar filamin repeats: implication on filamin-medite receptor clustering and cross-talking. J. Biol. Chem., 284:35113-21, 2009. PMID: 19828450
  7. Yang, J., Ma, Y.Q., Page, R., Misra, S., Plow, E.F., and Qin, J. Structure of an integrin αIIbβ3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc. Natl. Acad. Sci., 106:17729-17734, 2009. PMID: 19805198
  8. Fukuda, K., Gupta, S., Chen, K., Wu, C., and Qin, J. The pseudo active site of ILK is essential for its binding to a-parvin and localization to focal adhesions. Molecular Cell, 36:819-830, 2009. PMID: 20005845
  9. Goksoy, E., Ma, Y.Q., Kong, X., Perera, D., Plow, E.F., and Qin, J. Structural basis for the autoinhibition of talin in regulating integrin activation. Molecular Cell, 31:124-33, 2008. PMID: 18614051
  10. Ma, Y., Qin, J., Wu, C., and Plow, E.F. Kindlin-2 (MIg-2): a co-activator of beta3 integrins. J. Cell Biol., 181(3):439-46, 2008. PMID: 18458155
  11. Wang, X., Fukuda, K., Byeon, I.J., Velyvis, A., Wu, C., Gronenborn, A.M., and Qin, J. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. J. Biol. Chem., 283:21113-21119, 2008. PMID: 18508764
  12. Wang, W., Liao, X., Fukuda, K., Knappe, S., Wu, F., Dries, D.L., Qin, J., and Wu, Q.Y. Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and pro-atrial natriuretic peptide processing activity. Circulation Research, 103:502-508, 2008. PMID: 18669922
  13. Greenberg, M.E., Li, X.M., Gugiu, B.G., Gu, X.D., Qin, J., Salomon, R.G., and Hazen, S.L. The lipid whisker model of the structure of peroxidized cell membranes. J. Biol. Chem., 283(4):2385-96, 2008. PMID: 18045864
  14. Shi, X., Tu, Y., Chen, K., Wu, S., Fukuda, K., Ma, YQ., Qin, J., Plow, E.F.P., and Wu, C. The mitogen inducible gene-2 (Mig-2)-integrin interaction promotes cytoskeletal strengthening of cell-matrix adhesion and modulates cell motility. J. Biol. Chem., 282(28):20455-66, 2007.
  15. Deshmukh, L., Tyukhtenko, S., Liu, J.M., Fox, J., Qin, J., and Vinogradova, O. Molecular insight into the interaction between platelet integrin αIIbβ3 and cytoskeletal protein skelemin. J. Biol. Chem., 282(44):32349-56, 2007.
  16. Li, X.M., Salomon, R.G., Qin, J., and Hazen, S.L. Conformation of an endogenous oxidized phospholipid ligand for the macrophage scavenger receptor CD36. Biochemistry, 46, 5009-17, 2007.
  17. Ma, Y.Q., Qin, J., and Plow, E.F. Platelet Integrin αIIbβ3: Activation Mechanisms. J. Thromb. Haemost., 5, 1345-52, 2007.
  18. Li, S., Peters, G., Ding, K., Zhang, X., Qin, J., and Sen, G. Molecular Basis of PKR Activation by PACT. Proc. Natl. Acad. Sci. 103(26):10005-10, 2006.
  19. Vaynberg, J. and Qin, J. Weak protein-protein interactions by NMR. Trends in Biotechnology, 24(1):22-7, 2006.
  20. Xu, Y., Wang, X, Yang, J., Vaynberg, J., and Qin, J. PASA – a program for automated sequential assignment by pattern-filtering approach. J. Biomol. NMR 1, 41-56, 2006.
  21. Ding, K., Ithychanda, S., and Qin, J. 3D Correlated Accordion NMR Spectroscopy of Proteins. J. Mag. Reson., 180:203-9, 2006.
  22. Kong, X., Wang, X., Misra, S., and Qin, J. Structural basis for the phosphorylation-regulated focal adhesion targeting of type Iγ phosphatidylinositol phosphate kinase (PIPKIγ) by talin. J. Mol. Biol., 359:47-54, 2006.
  23. Ma, Y.Q., Yang, J., Pesho, M., Vinogradova, O., Qin, J., and Plow, E.F. Molecular insight into the regulation of integrin αIIbβ3 activation by distinct regions of its cytoplasmic tails. Biochemistry, 45(21):6656-62, 2006.
  24. Vaynberg, J., Fukuda, T., Chen, K., Vinogradova, O., Velyvis, A., Tu, Y., Ng, L., Wu, C. and Qin, J. Structure of an ultra weak protein-protein complex and its crucial role in regulation of cell morphology and motility. Molecular Cell, 17:513-523, 2005.
  25. De, S., Razorenova, O., McCabe, N., O’Toole, T., Qin, J., and Byzova, T. Integrin activation and clustering controls tumor growth and vascularization. Proc. Natl. Acad. Sci., 102(21):7589-94, 2005.
  26. Vinogradova, O., Vaynberg, J., Kong, X., Haas, T.A., Plow, E.F. Qin, J. Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc. Natl. Acad. Sci., 101:4094-9, 2004.
  27. Qin, J., Vinogradova, O., Plow, E.F. Integrin Bidirectional Signaling: A Molecular View. PloS Biology. (Invited review) 2:726-9, 2004.
  28. Velyvis A, Vaynberg, J., Yang, Y., Vinogradova O, Zhang, Y., Wu, C., Qin J. Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. Nature Struct. Biol., 10, 558-564, 2003.
  29. Vinogradova, O., Velyviene, A., Velyvis, A., Haas, T., Plow, E.F., and Qin, J. A structural mechanism of integrin αIIbβ3 ‘inside-out’ activation as regulated by its cytoplasmic face. Cell, 110, 587-597. 2002.
  30. Shi, Y., Krishnamoorthy, G., Yang, Y., Hu, L., Chaturvedi, N., Harilal, D., Qin, J. and Cui, J. Mechanism of magnesium activation of calcium-activated potassium channels. Nature, 418:876-880, 2002.
  31. Velyvis, A., Yang, Y., Rahman, F., and Qin, J. Solution Structure of Focal Adhesion Adaptor PINCH LIM1 Domain and Its Interaction with the Ankyrin Repeat Domain of Integrin-linked Kinase. J. Biol. Chem., 276:4932-4939, 2001.
  32. Vinogradova, O., Haas, T., Plow, E.F., and Qin, J. A Structural Basis for Integrin Activation by the Cytoplasmic Tail of the αIIb Subunit. Proc. Natl. Acad. Sci., 76, 1450-55, 2000.
  33. Nanduri, S., Rahman, F., Williams, BRG, and Qin, J. A dynamically-tuned double stranded RNA binding mechanism for the activation of antiviral protein kinase PKR. EMBO J., 19, 5567-5574, 2000.
  34. Nanduri, S., Carpick, B., Yang, Y., Williams, B., and Qin, J. Structure of the double stranded RNA (dsRNA) binding domain of the human interferon-induced protein kinase (PKR) reveals the molecular basis of its dsRNA-mediated activation. EMBO J., 17, 5458-5465, 1998.