Key References:

  1. Horowitz, A., and M. Simons. Phosphorylation of the Cytoplasmic Tail of Syndecan-4 Regulates Activation of Protein Kinase Ca. J. Biol. Chem., 273: 25548-25551, 1998.
  2. Horowitz, A., M. Murakami, and M. Simons. Phosphatidylinositol-4,5-bisphosphate Mediates the Interaction of Syndecan-4 with Protein Kinase C. Biochem., 38: 15871-15877, 1999.
  3. Simons, M., and A. Horowitz. Syndecan-4-mediated signaling. Cell Signal. 13: 855-862, 2001.
  4. Horowitz, A., E. Tkachenko, and M. Simons. Fibroblast Growth Factor-specific Modulation of Cellular Response by Syndecan-4. J. Cell Biol., 157: 715-725, 2002.
  5. Murakami, M., A. Horowitz, S. Tang, J.A. Ware, and M. Simons. PKCd Regulates PKCa in a syndecan-4 dependent manner. J. Biol. Chem., 277: 20367-20371, 2002.
  6. Liu, M ., and A. Horowitz. A PDZ motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol. Biol. Cell, 17: 1880-1887, 2006.
  7. Chittenden, T.W., F. Claes, A.A. Lanahan, K.L. Moodie, M. Autiero, R.T. Palac, E.V. Tkachenko, A. Elfenbein, M. Drinane, E. Dedkov, R. Tomanek, W. Li, J. Singh, A. Horowitz, M. Mulligan-Kehoe, Z.W. Zhuang, J.D. Pearlman, P. Carmeliet and M. Simon. Synectin-dependent regulation of arterial branching. Dev. Cell, 10: 783-795, 2006.
  8. Naccache, S. N., T. Hasson, and A. Horowitz. Binding of Internalized Receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. PNAS, 103: 12735–12740, 2006.
  9. Salikhova, A., L. Wang, A. A. Lanahan, M. Simons, D. Mukhopadhyay, and A. Horowitz. Vascular Endothelial Growth Factor and Semaphorin Induce Neuropilin-1 Endocytosis via Separate Pathways. Circ. Res., 103: e71-e79, 2008.
  10. Garnaas, M. K., M. Liu, K. Li, J. Baraban, A. Horowitz*, and R. Ramchandran*. Syx, a novel RhoA guanine exchange factor, is essential for angiogenesis in vivo. (* – equal contribution). Circ. Res., 103: 710-716, 2008.
  11. Horowitz, A., and Simons, M. Branching Morphogenesis. Circulation Research 103: 784-795, 2008.
  12. Ernkvist, M., N. Luna-Persson, S. Audebert, P. Lecine, I. Sinha, M. Liu, A. Bratt, K. Aase, A. Majumdar, A. Horowitz, J. Borg, and L. Holmgren. The Amot/Patj?Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood, 113: 244-53, 2008. PMID: 18824598
  13. Horowtiz, A. Imaging of growth factor-augmented angiogenesis after myocardial infarction: glimmers of a spatiotemporal pattern? J. Mol. Cell Cardiol. 2009, Nov. 11. [Epub ahead of print] PMID: 19913025