Key References:

Fox JEB, Taylor RG, Taffarel M, Boyles JK, and Goll DE. (1993) Evidence that activation of platelet calpain is induced as a consequence of binding of adhesion ligand to the integrin, glycoprotein IIb-IIIa. J. Cell Biol. 120:1501-1507.

Fox JEB, Lipfert L, Clark EA, Reynolds CC, Austin CD, and Brugge JS. (1993) On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. J. Biol. Chem. 268:25973-25984.

Meyer SC and Fox JEB. (1995) Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. J. Biol. Chem. 270:14693-14699.

Earnest JP, Santos GF, Zuerbig S, and Fox JEB. (1995) Dystrophin-related protein in the platelet membrane skeleton. Integrin-induced change in detergent-insolubility and cleavage by aggregating platelets. J. Biol. Chem. 270:27259-27265.

Fox, JEB. (1996) Platelet activation: novel aspects. Haemostasis. 26:102-131.

Meyer, SC, Zuerbig, S, Cunningham, CC, Hartwig, JH, Bissell, T, Gardner, K, and Fox, JEB. (1997) Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein Ib alpha. J. Biol. Chem. 272:2914-2919.

Meyer, SC, Sanan, DA, and Fox JEB. (1998) Role of actin-binding protein in insertion of adhesion receptors into the membrane. J. Biol. Chem. 273:3013-3020.

Reddy, K.B., Gascard, P., Price, M.G., Negrescu, E.V., and Fox, J.E.B. (1998) Identification of an interaction between the M-band protein skelemin and integrin b -subunits. Colocalization of skelemin with b 3-containing integrin in non-muscle cells. J. Biol. Chem. 273:35039-35047.

Fox, J.E.B. and Saido, T.C. (1999) Calpain in signal transduction. In: The Pharmacology and Toxicology of Calpain (K.K.W. Wang and P-W. Yuen, eds.) Taylor and Francis, Washington, D.C. (103-126).

Kulkarni, S., Saido, T.C., Suzuki, K., and Fox, J.E.B. (1999) Calpain mediates integrin-induced signaling at a point upstream of Rho-family members. J. Biol. Chem. 274:21265-21275.

Zaffran, Y., Meyer, S.C., Negrescue, E., Reddy, K.B., and Fox J.E.B. (2000) Signaling across the platelet adhesion receptor GP Ib-IX induces a IIb b 3 activation both in platelets and a Chinese Hamster Ovary cell system. J. Biol. Chem. 275:16779-16787.

Bialkowska, K., Kulkarni, S., and Fox, J.E.B. (2000) Evidence that b 3-integrin induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active. J. Cell Biol. 151:685-696.

Reddy, K.B., Bialkowska, K., and Fox, J.E.B. (2001) Dynamic modulation of cytoskeletal proteins linking integrins to signaling complexes in spreading cells: role of skelemin in initial integrin-induced spreading (the first two authors contributed equally). J. Biol. Chem. 276:28300-28308.

Fox, J.E.B . (2001) Cytoskeletal proteins and platelet signaling. In: Thrombosis and Haemostasis (A. Nurden, ed.) International Society on Haemostasis and Thrombosis and Slack Inc. Thromb. Haemost. 86:198-213.

Fox, J.E.B . (2001) The platelet cytoskeleton. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (Colman, Hirsh, Marder, Clowes, and George, eds.) Lippincott-Raven Publishers. (429-446).

Kulkarni, S. and Fox, J.E.B. (2002) Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreading . J. Biol. Chem. 277:24435-24441.

Bialkowska, K., Zaffran Y., Meyer, S.C., and Fox, J.E.B . (2003) 14-3-3zeta mediates integrin-induced activation of Cdc42 and Rac: platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta. J. Biol. Chem . 278:33342-33350.

Bialkowska, K., Saido, T.C., and Fox, J.E.B . (2005) SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. J. Cell Sci. 118:381-395.

Reddy, K., Fox, J.E.B., Price, M.G., Gupta, S., Kulkarni, S., Smith, D.M. (2008) Nuclear localization of Myomesin-1: possible functions. J. Muscle Research and Cell Motility. 29:1-8.

Podolnikova, N.P., O'Toole, T.E., Haas, T.A., Lam, S.C-T., Fox, J.E.B. & Ugarova, T.B. (2009) Adhesion- induced unclasping of cytoplasmic tails of integrin alpha(IIb)beta3. Biochemistry 48:617-29. PMID:19117493