Investigators

• Martin, Bradley Graduate Student
• Bulek, Katarzyna Postdoctoral Fellow
• Gulen, M. Fatih Postdoctoral Fellow
• He, Zhu Predoctoral Fellow
• Herjan, Tomek Postdoctoral Fellow
• Kang, Zizhen Research Associate
• Liu, Caini Research Associate
• Qian, Wen Research Associate
• Swaidani, Shadi Research Associate
• Wang, Chenhui Postdoctoral Fellow
• Wei, Cui Predoctoral Fellow
• Wu, Ling Graduate Student
• Yu, Minjia Student
• Zepp, Jarod Graduate Student
• Zhao, Hoa Graduate Student
• Zhao, Junjie Graduate Student

Collaborators

Publications

Gulen M. F., Kang Z. , Bulek K., Youzhong W., Kim T. W. , Chen Y., Altuntas C. Z., Bak-Jenson K. , McGeachy M. J., Do J. S. , Xiao H., Delgoffe G. M. , Min B., Powell J. D., Tuohy V. K., Cua D. J., Li X. (in press) The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation. Immunity.

Kang Z., Altuntas C, Gulen MF, Liu C , Giltiay N, Qin H, Ransohoff R, Bergmann C, Stohlman S, Tuohy V, Li X. (2010) Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis. Immunity

Swaidani S., K.Bulek, Z.Kang, C.Liu, Y.Lu, W.Yin, M.Aronica, and Li X (2009) The Critical Role of Epithelial-Derived Act1 in IL-17- and IL-25-Mediated Pulmonary Inflammation. J.Immunol. 182:1631-1640.

Hartupee J, Li X and Hamilton T (2009) IL-17 signaling for mRNA stabilization does not required TRAF6. J. Immunol. 182:1660-6

Bulek K, Swaidani S, Qin J, Lu Y, Gulen M, Herjan T, Min B, Kastelein R, Aronica M, Li X (2009) The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response. J. Immunol.

Wan Y, Thomas J, Li X (2009) Interleukin-1 Receptor-associated Kinase 2 Is Critical for
Lipopolysaccharide-mediated Post-transcriptional Control. J. Biol. Chem.

Staschke K, Dong S, Saha J, Zhao J, Brooks N, Hepburn D, Xia J, Gulen M, Kang Z, Altuntas C, Tuohy V, Gilmour R, Li X and Na S (2009) IRAK4 kinase Activity is Required for Th17 Differentiation and TH17 -Mediated Disease. J. Immunol.

Liu C, Qian W, Qian, Giltiay G, Misra S, Chen Z, and Li X (2009) Act1, a U-box E3 ubiquitin ligase for IL-17R signaling. Science Signaling

Xiao H, Gilmour R, and Li X . (2008) Pellino 3b negatively regulates IL-1-induced TAK1-dependent NF k B activation. J. Biol. Chem.

Hartupee J, Li X and Hamilton T (2008) Interleukin 1
-induced NFB Activation and Chemokine mRNA Stabilization Diverge at IRAK1. J. Biol. Chem. 283:15689-93.

Von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Aróstegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yagüe J, Antón J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Maródi L, Rodriguez-Gallego C, Banchereau J, Abel L , Li X, Chaussabel D, Puel A, Casanova JL. (2008) Pyogenic bacterial infections in humans with MyD88 deficiency. Science 321: 691-6.

Fraczek J, Kim T, Xiao H, Yao J, Wen Q, Yali Li, Jean-Laurent Casanova, and Li X (2008) The kinase activity of IRAK4 is required for IL-1R/TLR-induced TAK1-dependent NFkappa B activation. J. Biol. Chem.

Qian Q, Giltiay G, Scott M, Robert Carter; Trine N. Jorgensen; and Li X (2008) Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren's syndrome. Euro. J. Immunol.