Research interest
Tumor Immunology - Studying how cancers actively induce suppressor cells as part of immune evasion.
Cancer Therapy Resistance - Studying how oncogenes known to have anti-apoptotic properties have in addition anti-senescent functions rendering tumors chemotherapy resistant.
Current program
- Tumor Immunology - We are developing not only animal models to better understand this process, but also as a basis to investigate novel inhibitory strategies to enhance current immunotherapeutic approaches. Tumor secreted factors also appear to be an important part of this process, and thus identifying them and creating reagents for study and inhibition is also part of our investigations.
- Cancer Therapy Resistance - We are moving toward a better understanding of these oncogenes from a molecular and biochemical standpoint as they inhibit chemotherapy induced senescence. Our goal is to identify new molecules involved in this process and new inhibitors of these oncogenes that will ultimately have clinical utility.
Publications
Moche JA, Chopra K, Gastman B. Vascularized Free Fibula for Cervical Spine Reconstruction following Complicated Retropharyngeal Abscess. Otolarygology Head and Neck Surgery ahead of publication.
Gastman B. Reply: excising value at a marginal cost: rethinking the management of Basal cell carcinoma.
Plast Reconstr Surg. 2011 May;127(5):2137.
Maniar A, Zhang X, Lin W, Gastman BR, Pauza
CD, Strome SE, Chapoval AI. Human
{gamma}{delta} T lymphocytes induce robust NK cell mediated antitumor cytotoxicity
through CD137 engagement. Blood.
Sep 9;116(10):1726-33. 2010
Han J, Goldstein LA, Hou W, Gastman BR, Rabinowich H. Regulation
of mitochondrial apoptotic events by p53-mediated disruption of complexes
between anti-apoptotic Bcl-2 members and Bim. J
Biol Chem. 2010 Jul 16;285(29):22473-83.
Zhang X, Voskens CJ, Sallin M, Maniar
A, Montes CL, Zhang Y, Lin W, Li G, Burch E, Tan M, Hertzano R, Chapoval AI,
Tamada K, Gastman BR, Schulze DH, Strome SE.
CD137 promotes proliferation and survival of human B cells. J Immunol.
Jan 15;184(2):787-95, 2010.
Gulleh Y, Silverman R, Goldebrg N, Gastman BR. What is the best surgical margin for a Basal cell carcinoma: a meta analysis of the literature. Plast Reconstr Surg. 2010 Oct;126(4):1222-31
Sumer B, Gastman BR, Haughey BH, Nussenbam B. Microvascular Reconstruction of the Laryngopharynx with Intent of Laryngeal Conservation. Archives of Otolaryngology, 135(8):801-6, 2009.
Alexander AA, Maniar A, Cummings JS, Hebbeler
AM, Schulze DH, Gastman BR, Pauza CD, Strome SE, Chapoval
A.
Isopentenyl pyrophosphate activated CD56+ ?d T lymphocytes display potent
anti-tumor activity towards human squamous cell carcinoma. Clinical
Cancer Research, 14 ( 13 ): 4232-40, 2008 .
Montes CL, Chapoval A, Nelson
J, Orhue V, Zhang X, Schulze DH, Strome SE, Gastman BR. Tumor-induced
senescent T cells with suppressor function: a potential form of tumor immune
evasion. Cancer Research, 68 ( 3 ): 870-9, 2008.
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