Area of Interest:
Cardiac and renal allograft rejection, vascular inflammation, innate immune responses.
Area of Interest:
Skin disease, Skin and cardiac allograft rejection, T cell recruitment to inflammation in peripheral tissues
Area of Interest:
Tumor immunity, T lymphocytes, signal transduction and transcription factors
Area of Interest:
Spatial organization and dynamics of B cell activation during an immune response
Area of Interest:
Autoimmunity; Systemic lupus erythematosus; Gender differences; The role of interferons in autoimmunity
Area of Interest:
Analysis of mechanisms regulating inflammatory gene expression in mononuclear phagocytes. Analysis of stimulus-dependent control of chemokine and cytokine mRNA stability.
Area of Interest:
Liver dendritic cells regulate hepatic immunity; Immunosuppressive activity of hepatic stellate cells
Area of Interest:
The complement system is an important part of the innate immunity. Complement activation products not only directly help to eliminate invading pathogens, but also participate in many immunological reactions, including clearance of immune complexes, antibody production, and T-cell regulation.
Area of Interest:
T cell homeostasis, Memory T cells, Role of basophils in adaptive immunity.
Area of Interest:
Our laboratory studies strategies to optimize the immune response to tumors for therapeutic purposes. We have found that we can sensitize T cells to weak tumor antigens in vaccine-draining lymph nodes and then purify recently stimulated T cells. These T cells can be activated in vitro to proliferate and acquire effector function and treat established tumor following adoptive transfer. We are currently working with a transgenic mouse model of HER2/neu breast cancer to define tumor-rejection antigens on cancer stem cells.
Area of Interest:
Transplantation Tolerance; Transplant Rejection; Liver Immunity; Dendritic Cell Biology; Co-stimulation; Transplant Microsurgery
Area of Interest:
Autoimmunity, Immunoregulation, T Cells, Gene Therapy
Area of Interest:
Transplant Immunology;Memory T Cells; T Cell Costimulation
