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Bin Zhang, Ph.D.Assistant StaffGenomic Medicine Institute (NE50) |
Academic Appointments: Assistant Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine.
Assistant Professor, Department of Biology, Geology, and Environmental Science, Cleveland State University.
Education and Training: PhD, Michigan State University, MI
Postdoctoral Fellowship, Howard Hughes Medical Institute, University of Michigan, MI
Selected Major Honors and Awards:
Basil O’Connor Starter Scholar Award, March of Dimes Foundation
Career Development Award, National Hemophilia Foundation
Merit Award, American Society of Hematology
Judith Graham Pool Postgraduate Fellowship, National Hemophilia Foundation
Research Insterest:
Our lab is interested in the role of intracellular protein trafficking in human diseases, focusing on protein transport from the endoplasmic reticulum (ER) to the Golgi body. Abnormal ER-to-Golgi trafficking has been associated with several genetic diseases, and may contribute to the pathogenesis of some common diseases. Currently much of our knowledge on the early secretory pathway has been gained from studies in simple model organisms such as yeast. Potential unique features and more complex mechanisms may underlie the ER-to-Golgi transport in mammalian cells. We are using transgenic mice to establish in vivo functions of several components of the early secretory pathway.
Selected Peer Reviewed Publications:
Zhang B*, Zheng C, Zhu M, Tao J, Vasievich M, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin. Blood. 118(12):3384-91. 2011. *Corresponding author
Zheng C, Liu HH, Yuan S, Zhou J, Zhang B. Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII. Blood. 116(25):5698-706. 2010.
Zheng C, Liu H, Zhou J, Zhang B. EF hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII. Blood. 115:1081-7. 2010.
Zhang B*, Spreafico M, Zheng CL, Yang A, Platzer PP, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EGD, Seligsohn U, Peyvandi F, Ginsburg D. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. Blood. 111:5592-600. 2008. *Corresponding author
Zhang B, Kaufman RJ, Ginsburg D. LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway. J. Biol. Chem., 280:25881-25886. 2005.