serre  

David Serre, Ph.D.

Assistant Staff

Genomic Medicine Institute
Lerner Research Institute / NE50
9500 Euclid Avenue
Cleveland, Ohio 44195

Telephone (office): 216 444-0676
Fax: 216 636-0009
serred@ccf.org

Academic Appointments:
Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine
Assistant Professor of Genetics, Case Western Reserve University

Education and Training:
Ph.D., Leipzig University-Max Planck Institute for Evolutionary Anthropology (Germany)
Postdoctoral fellowship, McGill University and Genome Quebec Innovation Centre (Canada)

Research Interests:
Our lab is interested in better understanding the genetic basis of common diseases in humans using genomic approaches. In particular, we are using high throughput sequencing to characterize genetic, epigenetic and transcriptomic variations in different biological systems. Current research in the lab includes:

  • Molecular bases and consequences of maternal obesity during gestation on the regulation of metabolic traits in mice
  • Epigenetic consequences of maternal obesity on human placenta
  • Whole genome sequencing of Malagasy Plasmodium vivax
  • Whole genome sequencing of Anopheles punctulatus sibling species


Research Assistant and Postdoctoral positions available

 

Selected Peer Reviewed Publications:

- Chan ER, HesterJ, Kalady M, Xiao H, Li X, Serre D (2011) A novel method for determining microflora composition using dynamic phylogenetic analysis of 16S ribosomal RNA deep sequencing data. Genomics 98(4:253-259.

- Serre D, Lee BH, Ting AH (2010) MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res. 38(2):391-399.

- Serre D, Gurd S, Ge B, Sladek R, Sinnett D, Dias C, Harmsen E, Bibikova M, Chudin E, Barker D, Dickinson T, Fan J-B and Hudson TJ (2008) Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic Cis-Acting Mechanisms Regulating Gene Expression. PLoS Genetics 4(2):e1000006.

- Serre D, Hudson TJ (2006) Resources for genetic variation studies. Annu Rev Genomics Hum Genet. 7:443-57.